製品の概要

  • 製品名
  • 製品の詳細
    Goat polyclonal to Smoothened
  • アプリケーション
    適用あり: WB, ELISAmore details
  • 種交差性
    交差種: Human
  • 免疫原

    Synthetic peptide:

    C-NLMDTELMDADSD

    , corresponding to C terminal amino acids 774-786 of Human Smoothened

  • ポジティブ・コントロール
    • Human Bone Marrow lysate.

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab58574 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB
ELISA
  • 追加情報
    Peptide ELISA: antibody detection limit dilution 1/32000.
    WB: Use at a concentration of 0.3 - 1 µg/ml. Detects a band of approximately 60 kDa (predicted molecular weight: 86 kDa).

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • ターゲット情報

    • 機能
      G protein-coupled receptor that probably associates with the patched protein (PTCH) to transduce the hedgehog's proteins signal. Binding of sonic hedgehog (SHH) to its receptor patched is thought to prevent normal inhibition by patched of smoothened (SMO). Required for the accumulation of KIF7 and GLI3 in the cilia.
    • 配列類似性
      Belongs to the G-protein coupled receptor Fz/Smo family.
      Contains 1 FZ (frizzled) domain.
    • 細胞内局在
      Membrane.
    • Information by UniProt
    • 参照データベース
    • 別名
      • Frizzled family member 11 antibody
      • FZD11 antibody
      • Gx antibody
      • Gx protein antibody
      • Protein Gx antibody
      • SMO antibody
      • SMO_HUMAN antibody
      • SMOH antibody
      • Smoothened frizzled family receptor antibody
      • Smoothened homolog (Drosophila) antibody
      • Smoothened homolog antibody
      • Smoothened homolog precursor (SMO) (Gx protein) antibody
      • Smoothened seven transmembrane spanning receptor antibody
      see all

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    プロトコール

    参考文献

    ab58574 has not yet been referenced specifically in any publications.

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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