Mouse, Rat, Horse, Dog, Xenopus laevis, Chimpanzee, Ferret, Rhesus monkey, Gorilla, Orangutan, Elephant
Synthetic peptide corresponding to SMC2. The epitope maps to a region between residues 950 and 1000 of human Structural Maintenance of Chromosomes 2 using the numbering given in entry NP_006435.1 (GeneID 10592)
Whole cell lysate from mock transfected or SMC2 transfected HEK293T cells.
保存方法Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
1/1000 - 1/10000. Detects a band of approximately 140 kDa (predicted molecular weight: 137 kDa).
機能Central component of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases.
配列類似性Belongs to the SMC family. SMC2 subfamily.
ドメインThe hinge domain, which separates the large intramolecular coiled coil regions, allows the heterodimerization with SMC4, forming a V-shaped heterodimer.
細胞内局在Nucleus. Cytoplasm. Chromosome. In interphase cells, the majority of the condensin complex is found in the cytoplasm, while a minority of the complex is associated with chromatin. A subpopulation of the complex however remains associated with chromosome foci in interphase cells. During mitosis, most of the condensin complex is associated with the chromatin. At the onset of prophase, the regulatory subunits of the complex are phosphorylated by CDC2, leading to condensin's association with chromosome arms and to chromosome condensation. Dissociation from chromosomes is observed in late telophase.
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Anti-SMC2 antibody 画像
Western blot - SMC2 antibody (ab10411)
Predicted band size : 137 kDa
ab10411 detection of human SMC2 by Western blot. Samples: Whole cell lysate (90 µg) from mock transfected (E) or SMC2 transfected (T) HEK293T cells. Antibody: ab10411 used at 0.1 µg/ml. Detection: Chemiluminescence with a 10 minute exposure.
Anti-SMC2 antibody (ab10411) 使用論文
has not yet been referenced specifically in any publications.