製品の概要

  • 製品名
  • 製品の詳細
    Rabbit polyclonal to SMARCD3
  • アプリケーション
    適用あり: WBmore details
  • 種交差性
    交差種: Mouse
    交差が予測される動物種: Rat, Rabbit, Horse, Chicken, Guinea pig, Cow, Cat, Dog, Human, Zebrafish
  • 免疫原

    Synthetic peptide from a region within amino acids 430-479 of Mouse SMARCD3 (NP_080167)

  • ポジティブ・コントロール
    • Mouse brain lysate

アプリケーション

Our Abpromise guarantee covers the use of ab115917 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 55 kDa. Good results were obtained when blocked with 5% non-fat dry milk in 0.05% PBS-T.

ターゲット情報

  • 機能
    Plays a role in ATP dependent nucleosome remodeling by SMARCA4 containing complexes. Stimulates nuclear receptor mediated transcription. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a post-mitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to post-mitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth.
  • 組織特異性
    Isoform 2 and isoform 1 are expressed in brain, heart, kidney, placenta, prostate, salivary gland, spleen, testis, thyroid, trachea and uterus. Isoform 1 is also expressed in skeletal muscle and adipose tissue.
  • 配列類似性
    Belongs to the SMARCD family.
    Contains 1 SWIB domain.
  • 細胞内局在
    Nucleus.
  • Information by UniProt
  • 参照データベース
  • 別名
    • 60 kDa BRG 1/Brm associated factor subunit C antibody
    • 60 kDa BRG-1/Brm-associated factor subunit C antibody
    • BAF60C antibody
    • BRG1 associated factor 60C antibody
    • BRG1-associated factor 60C antibody
    • Chromatin remodeling complex BAF60C subunit antibody
    • CRACD3 antibody
    • Mammalian chromatin remodeling complex BRG1 associated factor 60C antibody
    • MGC111010 antibody
    • Rsc6p antibody
    • Smarcd3 antibody
    • SMRD3_HUMAN antibody
    • SWI/SNF complex 60 kDa subunit C antibody
    • SWI/SNF related matrix associated actin dependent regulator of chromatin subfamily d member 3 antibody
    • SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3, isoform 1 antibody
    • SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 3 antibody
    • Swp73 like protein antibody
    see all

画像

  • Anti-SMARCD3 antibody (ab115917) at 1 µg/ml + Mouse brain lysate at 10 µg

    Predicted band size : 55 kDa

プロトコール

参考文献

This product has been referenced in:
  • Kumar S  et al. Functional screening of mammalian mechanosensitive genes using Drosophila RNAi library- Smarcd3/Bap60 is a mechanosensitive pro-inflammatory gene. Sci Rep 6:36461 (2016). ICC/IF ; Mouse . Read more (PubMed: 27819340) »

See 1 Publication for this product

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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