製品の概要

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab58188 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB Use a concentration of 1 - 5 µg/ml. This antibody has only been tested in WB against the recombinant fragment used as immunogen. We have no data on the detection of endogenous protein.

ターゲット情報

  • 機能Transcriptional coactivator cooperating with nuclear hormone receptors to potentiate transcriptional activation. Also involved in vitamin D-coupled transcription regulation via its association with the WINAC complex, a chromatin-remodeling complex recruited by vitamin D receptor (VDR), which is required for the ligand-bound VDR-mediated transrepression of the CYP27B1 gene. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a post-mitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to post-mitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth.
  • 関連疾患Nicolaides-Baraitser syndrome
  • 配列類似性Belongs to the SNF2/RAD54 helicase family.
    Contains 1 bromo domain.
    Contains 1 helicase ATP-binding domain.
    Contains 1 helicase C-terminal domain.
    Contains 1 HSA domain.
    Contains 1 QLQ domain.
  • 細胞内局在Nucleus.
  • Information by UniProt
  • 参照データベース
  • 別名
    • ATP dependent helicase SMARCA2 antibody
    • ATP-dependent helicase SMARCA2 antibody
    • BAF190 antibody
    • BAF190B antibody
    • BRG1-associated factor 190B antibody
    • BRM antibody
    • FLJ36757 antibody
    • Global transcription activator homologous sequence antibody
    • hBRM antibody
    • hSNF2a antibody
    • MGC74511 antibody
    • Possible global transcription activator SNF2L2 antibody
    • Probable global transcription activator SNF2L2 antibody
    • Protein brahma homolog antibody
    • SMARCA2 antibody
    • SMCA2_HUMAN antibody
    • SNF2 alpha antibody
    • SNF2 like 2 antibody
    • SNF2-alpha antibody
    • SNF2/SWI2 like protein 2 antibody
    • SNF2L2 antibody
    • SNF2LA antibody
    • Sth1p antibody
    • Sucrose nonfermenting 2 like protein 2 antibody
    • SWI/SNF related matrix associated actin dependent regulator of chromatin subfamily A member 2 antibody
    • SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 2 antibody
    see all

Anti-SMARCA2 / BRM antibody 画像

  • Western blot against tagged recombinant protein immunogen using ab58188 SMARCA2 / BRM antibody at 1ug/ml. Predicted band size of immunogen is 35 kDa

Anti-SMARCA2 / BRM antibody (ab58188) 使用論文

ab58188 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"