製品の概要

  • 製品名
  • 製品の詳細
    Goat polyclonal to SMAD9
  • 特異性
    Not expected to crossreact with SMAD1 or SMAD5.
  • アプリケーション
    適用あり: Sandwich ELISA, WBmore details
  • 種交差性
    交差種: Human
    交差が予測される動物種: Mouse, Rat, Chicken, Dog
  • 免疫原

    Synthetic peptide:

    C-HSEPLMPHNATYPD

    , corresponding to internal sequence amino acids 166-179 of Human SMAD9.

  • ポジティブ・コントロール
    • Human skin lysate.

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab48011 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
Sandwich ELISA Use a concentration of 1 - 2 µg/ml. Used as a reporter to detect captured recombinant SMAD9
WB Use a concentration of 0.3 - 1 µg/ml. Detects a band of approximately 50 kDa (predicted molecular weight: 52 kDa).

ターゲット情報

  • 機能
    Transcriptional modulator activated by BMP (bone morphogenetic proteins) type 1 receptor kinase. SMAD9 is a receptor-regulated SMAD (R-SMAD).
  • 組織特異性
    Expressed in heart, brain, placenta, lung, skeletal muscle, prostate, testis, ovary and small intestine. Also expressed in fetal brain, lung and kidney.
  • 関連疾患
    Pulmonary hypertension, primary, 2
  • 配列類似性
    Belongs to the dwarfin/SMAD family.
    Contains 1 MH1 (MAD homology 1) domain.
    Contains 1 MH2 (MAD homology 2) domain.
  • 翻訳後修飾
    Phosphorylated on serine by BMP (bone morphogenetic proteins) type 1 receptor kinase.
  • 細胞内局在
    Cytoplasm. Nucleus. In the cytoplasm in the absence of ligand. Migration to the nucleus when complexed with SMAD4.
  • Information by UniProt
  • 参照データベース
  • 別名
    • MAD homolog 9 antibody
    • Madh6 antibody
    • Mothers against decapentaplegic antibody
    • Mothers against decapentaplegic homolog 9 antibody
    • Mothers against DPP homolog 9 antibody
    • SMAD 9 antibody
    • SMAD family member 9 antibody
    • SMAD, mothers against DPP homolog 9 (Drosophila) antibody
    • SMAD8A antibody
    • SMAD8B antibody
    • Smad9 antibody
    • SMAD9_HUMAN antibody
    see all

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プロトコール

参考文献

ab48011 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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