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RabMAb

Anti-Smad3 (phospho S423 + S425) 抗体 [EP823Y] (ab52903)

ab52903 を使用した論文を発表された方は、こちらまでお知らせください。データシートに掲載させていただきます。

ab52903 は 97 報の論文で使用されています。

  • Lai CM  et al. Hedgehog signaling establishes precursors for germline stem cell niches by regulating cell adhesion. J Cell Biol 216:1439-1453 (2017). IHC ; Drosophila melanogaster . PubMed: 28363970
  • Han Y  et al. Mesenchymal Cell Reprogramming in Experimental MPLW515L Mouse Model of Myelofibrosis. PLoS One 12:e0166014 (2017). IF ; Mouse . PubMed: 28135282
  • Yue L  et al. Efficacy of ALK5 inhibition in myelofibrosis. JCI Insight 2:e90932 (2017). WB ; Human . PubMed: 28405618
  • Lefebvre P  et al. Interspecies NASH disease activity whole-genome profiling identifies a fibrogenic role of PPARa-regulated dermatopontin. JCI Insight 2:N/A (2017). WB ; Mouse . PubMed: 28679947
  • Shen J  et al. DNA methyltransferase 3b regulates articular cartilage homeostasis by altering metabolism. JCI Insight 2:N/A (2017). WB ; Mouse, Human . PubMed: 28614801
  • Xue R  et al. Polycaprolactone nanofiber scaffold enhances the osteogenic differentiation potency of various human tissue-derived mesenchymal stem cells. Stem Cell Res Ther 8:148 (2017). WB ; Human . PubMed: 28646917
  • Zeng Z  et al. Omega-3 Polyunsaturated Fatty Acids Attenuate Fibroblast Activation and Kidney Fibrosis Involving MTORC2 Signaling Suppression. Sci Rep 7:46146 (2017). WB . PubMed: 28393852
  • Redgrave RE  et al. Cardiosphere-Derived Cells Require Endoglin for Paracrine-Mediated Angiogenesis. Stem Cell Reports 8:1287-1298 (2017). PubMed: 28494939
  • Upadhyay M  et al. Transposon Dysregulation Modulates dWnt4 Signaling to Control Germline Stem Cell Differentiation in Drosophila. PLoS Genet 12:e1005918 (2016). PubMed: 27019121
  • Khalili H  et al. Identification and Characterization of a Novel Association between Dietary Potassium and Risk of Crohn's Disease and Ulcerative Colitis. Front Immunol 7:554 (2016). PubMed: 28003811
  • Kwan CW  et al. Functional evolution of a morphogenetic gradient. Elife 5:N/A (2016). PubMed: 28005004
  • Zhou Z  et al. Cerebral cavernous malformations arise from endothelial gain of MEKK3-KLF2/4 signalling. Nature 532:122-6 (2016). IHC . PubMed: 27027284
  • Omata M  et al. Hepatocyte Nuclear Factor-1ß Induces Redifferentiation of Dedifferentiated Tubular Epithelial Cells. PLoS One 11:e0154912 (2016). WB . PubMed: 27196561
  • Wu Q  et al. miR-489 inhibits silica-induced pulmonary fibrosis by targeting MyD88 and Smad3 and is negatively regulated by lncRNA CHRF. Sci Rep 6:30921 (2016). WB ; Mouse . PubMed: 27506999
  • Nakamichi R  et al. Mohawk promotes the maintenance and regeneration of the outer annulus fibrosus of intervertebral discs. Nat Commun 7:12503 (2016). WB . PubMed: 27527664
  • Ren J  et al. Quercetin Inhibits Fibroblast Activation and Kidney Fibrosis Involving the Suppression of Mammalian Target of Rapamycin and ß-catenin Signaling. Sci Rep 6:23968 (2016). WB, IF, IHC . PubMed: 27052477
  • Cao J  et al. Single epicardial cell transcriptome sequencing identifies Caveolin 1 as an essential factor in zebrafish heart regeneration. Development 143:232-43 (2016). PubMed: 26657776
  • Hoare M  et al. NOTCH1 mediates a switch between two distinct secretomes during senescence. Nat Cell Biol 18:979-92 (2016). PubMed: 27525720
  • Wang Q  et al. Smad4-dependent suppressor pituitary homeobox 2 promotes PPP2R2A-mediated inhibition of Akt pathway in pancreatic cancer. Oncotarget 7:11208-22 (2016). PubMed: 26848620
  • Chen PY  et al. Smooth muscle FGF/TGFß cross talk regulates atherosclerosis progression. EMBO Mol Med 8:712-28 (2016). PubMed: 27189169
  • Sato N  et al. Metformin attenuates lung fibrosis development via NOX4 suppression. Respir Res 17:107 (2016). Human . PubMed: 27576730
  • Tappeiner C  et al. Inhibition of the TGFß Pathway Enhances Retinal Regeneration in Adult Zebrafish. PLoS One 11:e0167073 (2016). IHC-P ; Zebrafish . PubMed: 27880821
  • Klein JD  et al. c-Fos Repression by Piwi Regulates Drosophila Ovarian Germline Formation and Tissue Morphogenesis. PLoS Genet 12:e1006281 (2016). Drosophila melanogaster . PubMed: 27622269
  • Chen JL  et al. Differential Effects of IL6 and Activin A in the Development of Cancer-Associated Cachexia. Cancer Res 76:5372-82 (2016). PubMed: 27328730
  • Soofi A  et al. The kielin/chordin-like protein KCP attenuates nonalcoholic fatty liver disease in mice. Am J Physiol Gastrointest Liver Physiol 311:G587-G598 (2016). PubMed: 27514479
  • Neto M  et al. Increased avidity for Dpp/BMP2 maintains the proliferation of progenitors-like cells in the Drosophila eye. Dev Biol 418:98-107 (2016). IHC-P ; Drosophila melanogaster . PubMed: 27502436
  • Marro J  et al. Collagen XII Contributes to Epicardial and Connective Tissues in the Zebrafish Heart during Ontogenesis and Regeneration. PLoS One 11:e0165497 (2016). ICC/IF ; Zebrafish . PubMed: 27783651
  • Budi EH  et al. The insulin response integrates increased TGF-ß signaling through Akt-induced enhancement of cell surface delivery of TGF-ß receptors. Sci Signal 8:ra96 (2015). WB ; Mouse . PubMed: 26420907
  • Nyström A  et al. Losartan ameliorates dystrophic epidermolysis bullosa and uncovers new disease mechanisms. EMBO Mol Med 7:1211-28 (2015). WB ; Human . PubMed: 26194911
  • Aspalter IM  et al. Alk1 and Alk5 inhibition by Nrp1 controls vascular sprouting downstream of Notch. Nat Commun 6:7264 (2015). Mouse . PubMed: 26081042
  • Chen JL  et al. Development of novel activin-targeted therapeutics. Mol Ther 23:434-44 (2015). PubMed: 25399825
  • Yousef H  et al. Systemic attenuation of the TGF-ß pathway by a single drug simultaneously rejuvenates hippocampal neurogenesis and myogenesis in the same old mammal. Oncotarget 6:11959-78 (2015). WB ; Mouse . PubMed: 26003168
  • Bravi L  et al. Sulindac metabolites decrease cerebrovascular malformations in CCM3-knockout mice. Proc Natl Acad Sci U S A 112:8421-6 (2015). PubMed: 26109568
  • Quigley HA  et al. Losartan Treatment Protects Retinal Ganglion Cells and Alters Scleral Remodeling in Experimental Glaucoma. PLoS One 10:e0141137 (2015). PubMed: 26505191
  • Newton FG  et al. Coordinate post-transcriptional repression of Dpp-dependent transcription factors attenuates signal range during development. Development 142:3362-73 (2015). In situ hybridization ; Drosophila melanogaster . PubMed: 26293305
  • Li J  et al. Rictor/mTORC2 signaling mediates TGFß1-induced fibroblast activation and kidney fibrosis. Kidney Int 88:515-27 (2015). WB ; Rat . PubMed: 25970154
  • Qian F  et al. Cross regulation between hypoxia-inducible transcription factor-1a (HIF-1a) and transforming growth factor (TGF)-ß1 mediates nickel oxide nanoparticles (NiONPs)-induced pulmonary fibrosis. Am J Transl Res 7:2364-78 (2015). WB . PubMed: 26807184
  • Zhao L  et al. Bufalin inhibits TGF-ß-induced epithelial-to-mesenchymal transition and migration in human lung cancer A549 cells by downregulating TGF-ß receptors. Int J Mol Med : (2015). Human . PubMed: 26133118
  • Maquigussa E  et al. Calcitriol ameliorates renal damage in a pre-established proteinuria model. Mol Med Rep 12:1009-15 (2015). WB . PubMed: 25823676
  • Cui W  et al. Hypoxia induces calpain activity and degrades SMAD2 to attenuate TGFß signaling in macrophages. Cell Biosci 5:36 (2015). WB . PubMed: 26146544
  • Priyadarsini S  et al. Keratoconus in vitro and the key players of the TGF-ß pathway. Mol Vis 21:577-88 (2015). WB . PubMed: 26015770
  • Loiselle AE  et al. Development of antisense oligonucleotide (ASO) technology against Tgf-ß signaling to prevent scarring during flexor tendon repair. J Orthop Res 33:859-66 (2015). PubMed: 25761254
  • Chatterjee A  et al. Rapamycin-induced G1 cell cycle arrest employs both TGF-ß and Rb pathways. Cancer Lett 360:134-40 (2015). PubMed: 25659819
  • Hirota S  et al. Neuropilin 1 balances ß8 integrin-activated TGFß signaling to control sprouting angiogenesis in the brain. Development 142:4363-73 (2015). PubMed: 26586223
  • Tobar N  et al. c-Jun N terminal kinase modulates NOX-4 derived ROS production and myofibroblasts differentiation in human breast stromal cells. BMC Cancer 14:640 (2014). WB ; Human . PubMed: 25175743
  • Hayashi A  et al. Inflammatory suppressive effect of prostate cancer cells with prolonged exposure to transforming growth factor ß on macrophage-differentiated cells via downregulation of prostaglandin E2. Oncol Lett 8:1513-1518 (2014). WB ; Human . PubMed: 25202359
  • Casari A  et al. A Smad3 transgenic reporter reveals TGF-beta control of zebrafish spinal cord development. Dev Biol 396:81-93 (2014). PubMed: 25286120
  • Biswas T  et al. Attenuation of TGF-ß signaling supports tumor progression of a mesenchymal-like mammary tumor cell line in a syngeneic murine model. Cancer Lett 346:129-38 (2014). PubMed: 24368187
  • Zerr P  et al. Vitamin D receptor regulates TGF-ß signalling in systemic sclerosis. Ann Rheum Dis N/A:N/A (2014). Human . PubMed: 24448349
  • Sulkowski M  et al. Postsynaptic glutamate receptors regulate local BMP signaling at the Drosophila neuromuscular junction. Development 141:436-47 (2014). PubMed: 24353060
  • Savar A  et al. Loss of epithelial p53 and av integrin cooperate through Akt to induce squamous cell carcinoma yet prevent remodeling of the tumor microenvironment. Oncogene N/A:N/A (2014). WB ; Mouse . PubMed: 24469034
  • Duffy DJ  et al. GSK3 inhibitors regulate MYCN mRNA levels and reduce neuroblastoma cell viability through multiple mechanisms, including p53 and Wnt signaling. Mol Cancer Ther 13:454-67 (2014). PubMed: 24282277
  • Tobar N  et al. Soluble MMP-14 produced by bone marrow-derived stromal cells sheds epithelial endoglin modulating the migratory properties of human breast cancer cells. Carcinogenesis N/A:N/A (2014). Human . PubMed: 24618373
  • Ma X  et al. Piwi is required in multiple cell types to control germline stem cell lineage development in the Drosophila ovary. PLoS One 9:e90267 (2014). IHC . PubMed: 24658126
  • O'Reilly S  et al. Interleukin-6 (IL-6) trans signaling drives a STAT3-dependent pathway that leads to hyperactive transforming growth factor-ß (TGF-ß) signaling promoting SMAD3 activation and fibrosis via Gremlin protein. J Biol Chem 289:9952-60 (2014). WB ; Human . PubMed: 24550394
  • Boudreau HE  et al. Wild-type and mutant p53 differentially regulate NADPH oxidase 4 in TGF-ß-mediated migration of human lung and breast epithelial cells. Br J Cancer 110:2569-82 (2014). Human . PubMed: 24714748
  • Wartlick O  et al. Growth control by a moving morphogen gradient during Drosophila eye development. Development 141:1884-93 (2014). PubMed: 24757005
  • Suragani RN  et al. Modified activin receptor IIB ligand trap mitigates ineffective erythropoiesis and disease complications in murine ß-thalassemia. Blood 123:3864-72 (2014). IHC-P ; Mouse . PubMed: 24795345
  • Maimon I  et al. Without children is required for Stat-mediated zfh1 transcription and for germline stem cell differentiation. Development 141:2602-10 (2014). Drosophila melanogaster . PubMed: 24903753
  • Pan L  et al. Protein competition switches the function of COP9 from self-renewal to differentiation. Nature 514:233-6 (2014). PubMed: 25119050
  • Guo T  et al. Adipocyte ALK7 links nutrient overload to catecholamine resistance in obesity. Elife 3:e03245 (2014). ICC/IF ; Mouse . PubMed: 25161195
  • Xu MY  et al. Stat3 signaling activation crosslinking of TGF-ß1 in hepatic stellate cell exacerbates liver injury and fibrosis. Biochim Biophys Acta 1842:2237-45 (2014). PubMed: 25092172
  • Tang MK  et al. Promyelocytic leukemia (PML) protein plays important roles in regulating cell adhesion, morphology, proliferation and migration. PLoS One 8:e59477 (2013). ICC/IF ; Mouse . PubMed: 23555679
  • Soofi A  et al. Kielin/chordin-like protein attenuates both acute and chronic renal injury. J Am Soc Nephrol 24:897-905 (2013). WB ; Mouse . PubMed: 23539757
  • Beckwith EJ  et al. Circadian period integrates network information through activation of the BMP signaling pathway. PLoS Biol 11:e1001733 (2013). IHC (PFA fixed) ; Drosophila melanogaster . PubMed: 24339749
  • Meyer C  et al. Caveolin-1 abrogates TGF-ß mediated hepatocyte apoptosis. Cell Death Dis 4:e466 (2013). WB ; Mouse . PubMed: 23328673
  • Chu IM  et al. Expression of GATA3 in MDA-MB-231 triple-negative breast cancer cells induces a growth inhibitory response to TGFß. PLoS One 8:e61125 (2013). WB . PubMed: 23577196
  • Chatterjee S  et al. Junctional adhesion molecule-a regulates vascular endothelial growth factor receptor-2 signaling-dependent mouse corneal wound healing. PLoS One 8:e63674 (2013). IHC-Fr ; Mouse . PubMed: 23667656
  • Maddaluno L  et al. EndMT contributes to the onset and progression of cerebral cavernous malformations. Nature 498:492-6 (2013). PubMed: 23748444
  • Chai Z  et al. Genetic Deletion of Cell Division Autoantigen 1 Retards Diabetes-Associated Renal Injury. J Am Soc Nephrol N/A:N/A (2013). PubMed: 23929772
  • Dzieran J  et al. Comparative analysis of TGF-ß/Smad signaling dependent cytostasis in human hepatocellular carcinoma cell lines. PLoS One 8:e72252 (2013). WB . PubMed: 23991075
  • Kim SS  et al. Nifedipine Induces Periostin Expression in Gingival Fibroblasts through TGF-beta. J Dent Res 92:1022-8 (2013). PubMed: 24004653
  • Zhu JN  et al. Smad3 Inactivation and MiR-29b Upregulation Mediate the Effect of Carvedilol on Attenuating the Acute Myocardium Infarction-Induced Myocardial Fibrosis in Rat. PLoS One 8:e75557 (2013). WB ; Mouse . PubMed: 24086569
  • Prakoura N  et al. Epithelial calreticulin up-regulation promotes profibrotic responses and tubulointerstitial fibrosis development. Am J Pathol 183:1474-87 (2013). PubMed: 24035512
  • Winbanks CE  et al. The bone morphogenetic protein axis is a positive regulator of skeletal muscle mass. J Cell Biol 203:345-57 (2013). PubMed: 24145169
  • Liu Y  et al. Transforming growth factor-ß (TGF-ß)-mediated connective tissue growth factor (CTGF) expression in hepatic stellate cells requires Stat3 signaling activation. J Biol Chem 288:30708-19 (2013). WB, ICC/IF ; Human . PubMed: 24005672
  • Ding ZY  et al. Transforming growth factor ß induces expression of connective tissue growth factor in hepatic progenitor cells through Smad independent signaling. Cell Signal 25:1981-92 (2013). Human . PubMed: 23727026
  • Chiu CS  et al. Increased muscle force production and bone mineral density in ActRIIB-Fc-treated mature rodents. J Gerontol A Biol Sci Med Sci 68:1181-92 (2013). WB ; Mouse . PubMed: 23525481
  • Ables ET & Drummond-Barbosa D Cyclin E controls Drosophila female germline stem cell maintenance independently of its role in proliferation by modulating responsiveness to niche signals. Development 140:530-40 (2013). IHC ; Drosophila melanogaster . PubMed: 23293285
  • Henderson NC  et al. Targeting of av integrin identifies a core molecular pathway that regulates fibrosis in several organs. Nat Med 19:1617-24 (2013). IHC-Fr ; Mouse . PubMed: 24216753
  • Mohazab L  et al. Critical role for avß6 integrin in enamel biomineralization. J Cell Sci 126:732-44 (2013). PubMed: 23264742
  • Zheng J  et al. Activation of hepatic stellate cells is suppressed by microRNA-150. Int J Mol Med 32:17-24 (2013). PubMed: 23604143
  • Bahammam M  et al. Requirement for active glycogen synthase kinase-3ß in TGF-ß1 upregulation of connective tissue growth factor (CCN2/CTGF) levels in human gingival fibroblasts. Am J Physiol Cell Physiol 305:C581-90 (2013). PubMed: 23824844
  • Matsubara T  et al. TGF-ß-SMAD3 signaling mediates hepatic bile acid and phospholipid metabolism following lithocholic acid-induced liver injury. J Lipid Res 53:2698-707 (2012). PubMed: 23034213
  • Sha W  et al. Loss of PPAR? expression by fibroblasts enhances dermal wound closure. Fibrogenesis Tissue Repair 5:5 (2012). IHC . PubMed: 22502865
  • Le VQ & Wharton KA Hyperactive BMP signaling induced by ALK2(R206H) requires type II receptor function in a Drosophila model for classic fibrodysplasia ossificans progressiva. Dev Dyn 241:200-14 (2012). PubMed: 22174087
  • Akiyama T  et al. A large bioactive BMP ligand with distinct signaling properties is produced by alternative proconvertase processing. Sci Signal 5:ra28 (2012). IHC ; Drosophila melanogaster . PubMed: 22472650
  • Chablais F & Jazwinska A The regenerative capacity of the zebrafish heart is dependent on TGFß signaling. Development 139:1921-30 (2012). IHC ; Zebrafish . PubMed: 22513374
  • Kim SH  et al. Smad3 and its phosphoisoforms are prognostic predictors of hepatocellular carcinoma after curative hepatectomy. Hepatobiliary Pancreat Dis Int 11:51-9 (2012). IHC ; Human . PubMed: 22251470
  • Zhang P  et al. Activation of Wnt11 by transforming growth factor-ß drives mesenchymal gene expression through non-canonical Wnt protein signaling in renal epithelial cells. J Biol Chem 287:21290-302 (2012). WB . PubMed: 22556418
  • Gardner A  et al. The critical role of TAK1 in accentuated epithelial to mesenchymal transition in obliterative bronchiolitis after lung transplantation. Am J Pathol 180:2293-308 (2012). PubMed: 22525462
  • Zieba A  et al. Intercellular variation in signaling through the TGF-ß pathway and its relation to cell density and cell cycle phase. Mol Cell Proteomics 11:M111.013482 (2012). PubMed: 22442258
  • Ding Z  et al. SMAD4-dependent barrier constrains prostate cancer growth and metastatic progression. Nature 470:269-73 (2011). WB ; Mouse . PubMed: 21289624
  • Michaeloudes C  et al. TGF-ß regulates Nox4, MnSOD and catalase expression, and IL-6 release in airway smooth muscle cells. Am J Physiol Lung Cell Mol Physiol 300:L295-304 (2011). WB ; Human . PubMed: 21131394
  • González AM  et al. Assessment of the protective effects of oral tocotrienols in arginine chronic-like pancreatitis. Am J Physiol Gastrointest Liver Physiol 301:G846-55 (2011). WB ; Rat . PubMed: 21852363
  • Dejima K  et al. Novel contact-dependent bone morphogenetic protein (BMP) signaling mediated by heparan sulfate proteoglycans. J Biol Chem 286:17103-11 (2011). WB ; Drosophila melanogaster . PubMed: 21454551
  • Cunningham MF  et al. S100A4 expression is increased in stricture fibroblasts from patients with fibrostenosing Crohn's disease and promotes intestinal fibroblast migration. Am J Physiol Gastrointest Liver Physiol 299:G457-66 (2010). WB ; Human . PubMed: 20489045

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