Anti-Smad1 (phospho S206) 抗体 (ab106093)

製品の概要

  • 製品名Anti-Smad1 (phospho S206) antibody
    Smad1 一次抗体 製品一覧
  • 製品の詳細
    Rabbit polyclonal to Smad1 (phospho S206)
  • 特異性ab106093 is specific for Human Smad1 phosphorylated at pS206. Reactivity with nonphosphorylated Human Smad1 is minimal by ELISA and western blot.
  • アプリケーション適用あり: WB, ELISAmore details
  • 種交差性
    交差種: Human
    交差が予測される動物種: Mouse, Rat, Sheep, Horse, Chicken, Cow, Dog, Pig, Chimpanzee, Drosophila melanogaster, Macaque Monkey, Gorilla, Opossum, Orangutan
  • 免疫原

    A phosphorylated synthetic peptide corresponding to amino acids surrounding serine 206 of Human Smad1.

  • ポジティブ・コントロール
    • HEPG2 whole cell lysates treated with BMP2, EGF, or NaCl.
  • 特記事項Expiration date is one year from date of opening.

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab106093 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB 1/500 - 1/2000. Predicted molecular weight: 52 kDa.
ELISA 1/5000 - 1/25000.

ターゲット情報

  • 機能Transcriptional modulator activated by BMP (bone morphogenetic proteins) type 1 receptor kinase. SMAD1 is a receptor-regulated SMAD (R-SMAD). SMAD1/OAZ1/PSMB4 complex mediates the degradation of the CREBBP/EP300 repressor SNIP1.
  • 組織特異性Ubiquitous. Highest expression seen in the heart and skeletal muscle.
  • 配列類似性Belongs to the dwarfin/SMAD family.
    Contains 1 MH1 (MAD homology 1) domain.
    Contains 1 MH2 (MAD homology 2) domain.
  • 翻訳後修飾Phosphorylated on serine by BMP type 1 receptor kinase.
    Ubiquitin-mediated proteolysis by SMAD-specific E3 ubiquitin ligase SMURF1.
  • 細胞内局在Cytoplasm. Nucleus. Cytoplasmic in the absence of ligand. Migrates to the nucleus when complexed with SMAD4. Co-localizes with LEMD3 at the nucleus inner membrane.
  • Information by UniProt
  • 参照データベース
  • 別名
    • BSP-1 antibody
    • BSP1 antibody
    • HsMAD1 antibody
    • JV4-1 antibody
    • JV41 antibody
    • MAD homolog 1 antibody
    • MAD mothers against decapentaplegic homolog 1 antibody
    • Mad related protein 1 antibody
    • Mad-related protein 1 antibody
    • MADH1 antibody
    • MADR1 antibody
    • Mothers against decapentaplegic homolog 1 antibody
    • Mothers against DPP homolog 1 antibody
    • SMA- AND MAD-RELATED PROTEIN 1 antibody
    • SMAD 1 antibody
    • SMAD family member 1 antibody
    • SMAD mothers against DPP homolog 1 antibody
    • Smad1 antibody
    • SMAD1_HUMAN antibody
    • TGF beta signaling protein 1 antibody
    • Transforming growth factor-beta-signaling protein 1 antibody
    see all

Anti-Smad1 (phospho S206) antibody 画像

  • All lanes : Anti-Smad1 (phospho S206) antibody (ab106093) at 1/500 dilution

    Lane 1 : HepG2 whole cell lysate, treated with PBS
    Lane 2 : HepG2 whole cell lysate, treated with BMP2 (5 ng/ml)
    Lane 3 : HepG2 whole cell lysate, treated with BMP2 (5 ng/ml)
    Lane 4 : HepG2 whole cell lysate, treated with NaCL

    Lysates/proteins at 15 µg per lane.

    Secondary
    HRP-conjugated a-Rabbit IgG at 1/3000 dilution

    Predicted band size : 52 kDa

Anti-Smad1 (phospho S206) antibody (ab106093) 使用論文

ab106093 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"