Anti-SLX4 抗体 (ab100997)

製品の概要

• 製品名Anti-SLX4 antibody
  SLX4 一次抗体 製品一覧
• 製品の詳細
  Rabbit polyclonal to SLX4
• アプリケーション適用あり: WBmore details
• 種交差性
  交差種: Human
  
• 免疫原

  Synthetic peptide conjugated to KLH derived from within residues 900 - 1000 of Human SLX4.

  Immunogen の所有権に関して

  (Peptide available as ab116498.)

• ポジティブ･コントロール
  • This antibody gave a positive signal in HEK293 and U2OS whole cell lysates.

製品の特性

• 製品の状態Liquid
• 保存方法Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.
• バッファーpH: 7.40
  Preservative: 0.02% Sodium azide
  Constituent: PBS
  Note: Batches of this product that have a concentration < 1mg/ml may have BSA added as a stabilising agent. If you would like information about the formulation of a specific lot, please contact our scientific support team who will be happy to help.
• Concentration information loading...
• 精製度Immunogen affinity purified
• ポリ/モノポリクローナル
• アイソタイプIgG
• 研究分野
  • Epigenetics and Nuclear Signaling
  • DNA / RNA
  • DNA Damage & Repair
  • Nucl. Excision Repair

  • Epigenetics and Nuclear Signaling
  • DNA / RNA
  • DNA Damage & Repair
  • Homologous Recomb.

  • Epigenetics and Nuclear Signaling
  • DNA / RNA
  • DNA Damage & Repair
  • Fanconi's Anemia

関連製品

• Compatible Secondaries
  • Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488) (ab150077)
  • Goat Anti-Rabbit IgG H&L (HRP) (ab205718)

アプリケーション

ターゲット情報

• 機能Regulatory subunit that interacts with and increases the activity of different structure-specific endonucleases. Has several distinct roles in protecting genome stability by resolving diverse forms of deleterious DNA structures originating from replication and recombination intermediates and from DNA damage. Component of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA. Has a preference for 5'-flap structures, and promotes symmetrical cleavage of static and migrating Holliday junctions (HJs). Resolves HJs by generating two pairs of ligatable, nicked duplex products. Interacts with the structure-specific ERCC4-ERCC1 endonuclease and promotes the cleavage of bubble structures. Interacts with the structure-specific MUS81-EME1 endonuclease and promotes the cleavage of 3'-flap and replication fork-like structures. SLX4 is required for recovery from alkylation-induced DNA damage and is involved in the resolution of DNA double-strand breaks.
• 配列類似性Belongs to the SLX4 family.
  Contains 1 BTB (POZ) domain.
• 翻訳後修飾Phosphorylated upon DNA damage, probably by ATM or ATR.
• 細胞内局在Nucleus. Localizes to sites of DNA dammage.

• Target information above from: UniProt accession Q8IY92 The UniProt Consortium
  The Universal Protein Resource (UniProt) in 2010
  Nucleic Acids Res. 38:D142-D148 (2010) .

  Information by UniProt
• 参照データベース
  • Entrez Gene: 84464 Human
  • Omim: 613278 Human
  • SwissProt: Q8IY92 Human
  • Unigene: 143681 Human
• 別名
  • BTB (POZ) domain containing 12 antibody
  • BTB/POZ domain-containing protein 12 antibody
  • BTBD12 antibody

  • FANCP antibody
  • KIAA1784 antibody
  • KIAA1987 antibody
  • MUS312 antibody
  • SLX 4 antibody
  • slx4 antibody
  • SLX4 structure-specific endonuclease subunit homolog (S. cerevisiae) antibody
  • SLX4_HUMAN antibody
  • Structure-specific endonuclease subunit slx4 antibody

  see all