Anti-SLPI 抗体 [31] (ab17157)
Key features and details
- Mouse monoclonal [31] to SLPI
- Suitable for: IHC-Fr
- Reacts with: Human
- Isotype: IgG1
Related conjugates and formulations
製品の概要
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製品名
Anti-SLPI antibody [31]
SLPI 一次抗体 製品一覧 -
製品の詳細
Mouse monoclonal [31] to SLPI -
由来種
Mouse -
特異性
The reactivity of the antibody with the isolated domains was evaluated using isolated domains of SLPI obtained by cleavage using partial acidic hydrolysis. Therefore, it is possible that the antibody will recognize other SLPI cleavage products generated by e.g. (microbial) proteases. -
アプリケーション
適用あり: IHC-Frmore details -
種交差性
交差種: Human -
免疫原
Full length native protein (purified) corresponding to Human SLPI. SLPI purified from sputum
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ポジティブ・コントロール
- PMN lysate
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特記事項
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
製品の特性
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製品の状態
Liquid -
保存方法
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles. -
バッファー
Preservative: 0.02% Sodium azide
Constituents: PBS, 0.1% BSA -
Concentration information loading...
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ポリ/モノ
モノクローナル -
クローン名
31 -
アイソタイプ
IgG1 -
研究分野
関連製品
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Alternative Versions
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Compatible Secondaries
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Isotype control
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Recombinant Protein
アプリケーション
The Abpromise guarantee
Abpromise保証は、 次のテスト済みアプリケーションにおけるab17157の使用に適用されます
アプリケーションノートには、推奨の開始希釈率がありますが、適切な希釈率につきましてはご検討ください。
アプリケーション | Abreviews | 特記事項 |
---|---|---|
IHC-Fr |
1/50.
|
特記事項 |
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IHC-Fr
1/50. |
ターゲット情報
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機能
Acid-stable proteinase inhibitor with strong affinities for trypsin, chymotrypsin, elastase, and cathepsin G. May prevent elastase-mediated damage to oral and possibly other mucosal tissues. -
組織特異性
Mucous fluids. -
配列類似性
Contains 2 WAP domains. -
細胞内局在
Secreted. - Information by UniProt
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参照データベース
- Entrez Gene: 6590 Human
- GenBank: NM_003064 Human
- Omim: 107285 Human
- SwissProt: P03973 Human
- Unigene: 517070 Human
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別名
- ALK 1 antibody
- ALK1 antibody
- ALP antibody
see all
データシートおよび資料
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Datasheet download
参考文献 (6)
ab17157 は 6 報の論文で使用されています。
- Wei Z et al. Inhibition of secretory leukocyte protease inhibitor (SLPI) promotes the PUMA-mediated apoptosis and chemosensitivity to cisplatin in colorectal cancer cells. Discov Oncol 14:1 (2023). PubMed: 36595102
- McElvaney OF et al. Protease-anti-protease compartmentalization in SARS-CoV-2 ARDS: Therapeutic implications. EBioMedicine 77:103894 (2022). PubMed: 35217407
- Huang Y et al. Reduced Expression of Antimicrobial Protein Secretory Leukoprotease Inhibitor and Clusterin in Chronic Rhinosinusitis with Nasal Polyps. J Immunol Res 2021:1057186 (2021). PubMed: 33506054
- Jin Y et al. Secretory leukocyte protease inhibitor suppresses HPV E6-expressing HNSCC progression by mediating NF-?B and Akt pathways. Cancer Cell Int 19:220 (2019). PubMed: 31462893
- Xu CB et al. microRNA-539 functions as a tumor suppressor in papillary thyroid carcinoma via the transforming growth factor ß1/Smads signaling pathway by targeting secretory leukocyte protease inhibitor. J Cell Biochem N/A:N/A (2019). PubMed: 30706537
- Wang X et al. Secretory leukocyte peptidase inhibitor expression and apoptosis effect in oral leukoplakia and oral squamous cell carcinoma. Oncol Rep 39:1793-1804 (2018). PubMed: 29436667