Anti-Slow Skeletal Myosin Heavy chain 抗体 [M14] (ab97715)


  • 製品名
    Anti-Slow Skeletal Myosin Heavy chain antibody [M14]
    Slow Skeletal Myosin Heavy chain 一次抗体 製品一覧
  • 製品の詳細
    Mouse monoclonal [M14] to Slow Skeletal Myosin Heavy chain
  • 由来種
  • 特異性
    This antibody does not react with SDS denatured myosin but reacts positively with non-denatured slow myosin.
  • アプリケーション
    適用あり: IHC-Fr, ELISA, ICC/IF, WBmore details
  • 種交差性
    交差種: Mouse, Rat, Chicken, Human
  • 免疫原

    Full length native protein (purified) (Human)

  • ポジティブ・コントロール
    • Slow Skeletal Muscle.
  • 特記事項

    Abcam is committed to meeting high standards of ethical manufacturing and has decided to discontinue this product by June 2019 as it has been generated by the ascites method. We are sorry for any inconvenience this may cause.


  • 製品の状態
  • 保存方法
    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid repeated freeze / thaw cycles.
  • バッファー
    Preservative: None
    Constituents: PBS
  • Concentration information loading...
  • ポリ/モノ
  • クローン名
  • アイソタイプ
  • 研究分野


Our Abpromise guarantee covers the use of ab97715 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
IHC-Fr Use at an assay dependent concentration.
ELISA Use at an assay dependent concentration.
ICC/IF Use at an assay dependent concentration.
WB Use at an assay dependent concentration.


  • 機能
    Muscle contraction.
  • 組織特異性
    Both wild type and variant Gln-403 are detected in skeletal muscle (at protein level).
  • 関連疾患
    Defects in MYH7 are the cause of cardiomyopathy familial hypertrophic type 1 (CMH1) [MIM:192600]. Familial hypertrophic cardiomyopathy is a hereditary heart disorder characterized by ventricular hypertrophy, which is usually asymmetric and often involves the interventricular septum. The symptoms include dyspnea, syncope, collapse, palpitations, and chest pain. They can be readily provoked by exercise. The disorder has inter- and intrafamilial variability ranging from benign to malignant forms with high risk of cardiac failure and sudden cardiac death.
    Defects in MYH7 are the cause of myopathy myosin storage (MYOMS) [MIM:608358]. In this disorder, muscle biopsy shows type 1 fiber predominance and increased interstitial fat and connective tissue. Inclusion bodies consisting of the beta cardiac myosin heavy chain are present in the majority of type 1 fibers, but not in type 2 fibers.
    Defects in MYH7 are the cause of scapuloperoneal myopathy MYH7-related (SPMM) [MIM:181430]; also known as scapuloperoneal syndrome myopathic type. SPMM is a progressive muscular atrophia beginning in the lower legs and affecting the shoulder region earlier and more severely than distal arm.
    Defects in MYH7 are a cause of cardiomyopathy dilated type 1S (CMD1S) [MIM:613426]. Dilated cardiomyopathy is a disorder characterized by ventricular dilation and impaired systolic function, resulting in congestive heart failure and arrhythmia. Patients are at risk of premature death.
    Defects in MYH7 are the cause of myopathy distal type 1 (MPD1) [MIM:160500]. MPD1 is a muscular disorder characterized by early-onset selective weakness of the great toe and ankle dorsiflexors, followed by weakness of the finger extensors. Mild proximal weakness occasionally develops years later after the onset of the disease.
  • 配列類似性
    Contains 1 IQ domain.
    Contains 1 myosin head-like domain.
  • ドメイン
    The rodlike tail sequence is highly repetitive, showing cycles of a 28-residue repeat pattern composed of 4 heptapeptides, characteristic for alpha-helical coiled coils.
    Each myosin heavy chain can be split into 1 light meromyosin (LMM) and 1 heavy meromyosin (HMM). It can later be split further into 2 globular subfragments (S1) and 1 rod-shaped subfragment (S2).
  • 細胞内局在
    Cytoplasm > myofibril. Thick filaments of the myofibrils.
  • Information by UniProt
  • 参照データベース
  • 別名
    • Beta myosin heavy chain antibody
    • cardiac muscle beta isoform antibody
    • CMD1S antibody
    • CMH1 antibody
    • MPD1 antibody
    • MYH7 antibody
    • MYH7_HUMAN antibody
    • Myhc slow antibody
    • MyHC-beta antibody
    • MyHC-slow antibody
    • MYHCB antibody
    • Myopathy, distal 1 antibody
    • Myosin heavy chain (AA 1-96) antibody
    • Myosin heavy chain 7 antibody
    • Myosin heavy chain antibody
    • Myosin heavy chain slow isoform antibody
    • Myosin heavy chain, cardiac muscle beta isoform antibody
    • Myosin, heavy chain 7, cardiac muscle, beta antibody
    • Myosin, heavy polypeptide 7, cardiac muscle, beta antibody
    • Myosin-7 antibody
    • Rhabdomyosarcoma antigen MU RMS 40.7A antibody
    • SPMD antibody
    • SPMM antibody
    see all


This product has been referenced in:
  • Dhoot GK Mammalian myoblasts become fast or slow myocytes within the somitic myotome. J Muscle Res Cell Motil 15:617-22 (1994). Read more (PubMed: 7706418) »

See 1 Publication for this product

レビューと Q&A

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