製品の概要

  • 製品名
    SLC5A8 peptide

製品の詳細

  • 由来
    Synthetic
  • アミノ酸配列
    • 配列
      GILVPFANSIGALVGLMAGFAISLWVGIGAQIYPPLPERTLPLHLDIQGC

関連製品

特性

Our Abpromise guarantee covers the use of ab117479 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • アプリケーション

    Blocking - Blocking peptide for Anti-SLC5A8 antibody (ab99064)

  • 製品の状態
    Liquid
  • Concentration information loading...

前処理および保存

  • 保存方法および安定性

    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

    Constituent: dH2O

関連情報

  • 別名
    • AIT
    • Apical iodide transporter
    • Electrogenic sodium monocarboxylate cotransporter
    • MGC125354
    • SC5A8_HUMAN
    • SLC5A8
    • SMCT
    • SMCT1
    • sodium coupled monocarboxylate transporter 1
    • Sodium iodide related cotransporter
    • Sodium iodide-related cotransporter
    • Sodium-coupled monocarboxylate transporter 1
    • solute carrier family 5 iodide transporter member 8
    • Solute carrier family 5 member 8
    see all
  • 機能
    Acts as an electrogenic sodium (Na(+)) and chloride (Cl-)-dependent sodium-coupled solute transporter, including transport of monocarboxylates (short-chain fatty acids including L-lactate, D-lactate, pyruvate, acetate, propionate, valerate and butyrate), lactate, mocarboxylate drugs (nicotinate, benzoate, salicylate and 5-aminosalicylate) and ketone bodies (beta-D-hydroxybutyrate, acetoacetate and alpha-ketoisocaproate), with a Na(+):substrate stoichiometry of between 4:1 and 2:1. Catalyzes passive carrier mediated diffusion of iodide. Mediates iodide transport from the thyrocyte into the colloid lumen through the apical membrane. May be responsible for the absorption of D-lactate and monocarboxylate drugs from the intestinal tract. Acts as a tumor suppressor, suppressing colony formation in colon cancer, prostate cancer and glioma cell lines. May play a critical role in the entry of L-lactate and ketone bodies into neurons by a process driven by an electrochemical Na(+) gradient and hence contribute to the maintenance of the energy status and function of neurons.
  • 組織特異性
    Expressed in normal thyroid, localized at the apical pole of thyroid cells facing the colloid lumen, but expression profoundly decreased in thyroid carcinomas. Expressed in normal colon but absent in colon aberrant crypt foci and colon cancers. Present in normal kidney cortex, brain, prostate, gastric mucosa and breast tissue but was significantly down-regulated in primary gliomas, gastric cancer, prostate tumors and breast tumors.
  • 配列類似性
    Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
  • 細胞内局在
    Apical cell membrane. Expressed at the apical membrane of normal tall thyrocytes and of colonic epithelial cells.
  • Information by UniProt

参考文献

ab117479 has not yet been referenced specifically in any publications.

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