製品の概要

  • 製品名
    Anti-SLC4A11 antibody
  • 製品の詳細
    Goat polyclonal to SLC4A11
  • 由来種
    Goat
  • アプリケーション
    適用あり: WBmore details
  • 種交差性
    交差種: Mouse, Rat, Human
    交差が予測される動物種: Rabbit, Horse, Chicken, Cow, Chimpanzee
  • 免疫原

    Synthetic peptide corresponding to Human SLC4A11 aa 109-123 (internal sequence) (Cysteine residue).
    Sequence:

    HTSRKYLKLKNFKEE


    Database link: NP_114423.1

  • ポジティブ・コントロール
    • WB: Human kidney tissue lysate.

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab99459 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB Use a concentration of 0.3 - 1 µg/ml. Detects a band of approximately 90 kDa (predicted molecular weight: 100 kDa).

ターゲット情報

  • 機能
    Transporter which plays an important role in sodium-mediated fluid transport in different organs. Prevents severe morphological changes of the cornea caused by increased sodium chloride concentrations in the stroma. In the inner ear, is involved in transport of potassium through the fibrocyte layer to the stria vascularis and is essential for the generation of the endocochlear potential but not for regulation of potassium concentrations in the endolymph. In the kidney, is essential for urinary concentration, mediates a sodium flux into the thin descending limb of Henle loop to allow countercurrent multiplication by osmotic equilibration (By similarity). Involved in borate homeostasis. In the absence of borate, it functions as a Na(+) and OH(-)(H(+)) channel. In the presence of borate functions as an electrogenic Na(+) coupled borate cotransporter.
  • 組織特異性
    Widely expressed. Highly expressed in kidney, testis, salivary gland, thyroid, trachea and corneal endothelium. Not detected in retina and lymphocytes.
  • 関連疾患
    Defects in SLC4A11 are the cause of corneal dystrophy and perceptive deafness (CDPD) [MIM:217400]; also known as corneal dystrophy and sensorineural deafness or Harboyan syndrome. CDPD consists of congenital corneal endothelial dystrophy and progressive perceptive deafness. Inheritance is autosomal recessive.
    Defects in SLC4A11 are the cause of corneal endothelial dystrophy type 2 (CHED2) [MIM:217700]; also known as congenital hereditary endothelial dystrophy of cornea. This bilateral corneal dystrophy is characterized by corneal opacification and nystagmus. Inheritance is autosomal recessive.
    Defects in SLC4A11 are the cause of corneal dystrophy Fuchs endothelial type 4 (FECD4) [MIM:613268]; also known as Corneal dystrophy Fuchs endothelial late-onset. It is an ocular disorder caused by loss of endothelium of the central cornea. It is characterized by focal wart-like guttata that arise from Descemet membrane and develop in the central cornea, epithelial blisters, reduced vision and pain. Descemet membrane is thickened by abnormal collagenous deposition.
  • 配列類似性
    Belongs to the anion exchanger (TC 2.A.31) family.
  • 翻訳後修飾
    Glycosylated.
  • 細胞内局在
    Cell membrane. Membrane.
  • Information by UniProt
  • 参照データベース
  • 別名
    • Bicarbonate transporter related protein 1 antibody
    • Bicarbonate transporter-related protein 1 antibody
    • BTR1 antibody
    • CDPD antibody
    • CHED2 antibody
    • Corneal endothelial dystrophy 2 autosomal recessive antibody
    • dJ794I6.2 antibody
    • FECD4 antibody
    • MGC126418 antibody
    • MGC126419 antibody
    • NaBC1 antibody
    • S4A11_HUMAN antibody
    • Slc4a11 antibody
    • Sodium bicarbonate transporter-like protein 11 antibody
    • Sodium borate cotransporter 1 antibody
    • Sodium coupled borate cotransporter 1 antibody
    • Solute carrier family 4 member 11 antibody
    • Solute carrier family 4 sodium bicarbonate transporter like member 11 antibody
    • Solute carrier family 4 sodium borate transporter member 11 antibody
    see all

画像

  • Anti-SLC4A11 antibody (ab99459) at 0.3 µg/ml + Human kidney lysate in RIPA buffer at 35 µg

    Developed using the ECL technique.

    Predicted band size: 100 kDa
    Observed band size: 90 kDa (why is the actual band size different from the predicted?)
    Additional bands at: 26 kDa. We are unsure as to the identity of these extra bands.



    Primary incubation was 1 hour.

プロトコール

参考文献

ab99459 has not yet been referenced specifically in any publications.

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