The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Use a concentration of 20 µg/ml.
Use a concentration of 1 - 2 µg/ml. Predicted molecular weight: 56 kDa.
Use at an assay dependent concentration.
機能May play a role in polarized cells by carrying out serosal-to-mucosal zinc transport. Plays a role in eye development. Could regulate the BMP/TGF-beta (bone morphogenetic protein/transforming growth factor-beta) signaling pathway and modulates extracellular matrix (ECM) proteins of the sclera (PubMed:24891338). Seems to play a central role in controlling organismal zinc status.
組織特異性Expressed in liver, kidney, pancreas, small intestine, colon, spleen, fetal liver and fetal kidney.
関連疾患Myopia 24, autosomal dominant
配列類似性Belongs to the ZIP transporter (TC 2.A.5) family.