製品の概要

  • 製品名Anti-SLC34A2 antibody
    SLC34A2 一次抗体 製品一覧
  • 製品の詳細
    Rabbit polyclonal to SLC34A2
  • アプリケーション適用あり: IHC-Pmore details
  • 種交差性
    交差種: Human
  • 免疫原

    antigen sequence: MRSLKPWDAV VSKFTGCFQM RCCCCCRVCC RACCLLCGCP KCCRCSKCCE DLEEAQEGQD VPVKAPETFD NITISREAQG EVPASDSKTE CT, corresponding to C terminal amino acids 597-688 of Human SLC34A2 protein (UniProt ID: O95436).

  • ポジティブ・コントロール
    • Human lung tissue

製品の特性

関連製品

アプリケーション

Our Abpromise guarantee covers the use of ab122431 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
IHC-P 1/200 - 1/500. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.

ターゲット情報

  • 機能May be involved in actively transporting phosphate into cells via Na(+) cotransport. It may be the main phosphate transport protein in the intestinal brush border membrane. May have a role in the synthesis of surfactant in lungs' alveoli.
  • 組織特異性Highly expressed in lung. Also detected in pancreas, kidney, small intestine, ovary, testis, prostate and mammary gland. In lung, it is found in alveolar type II cells but not in bronchiolar epithelium.
  • 関連疾患Defects in SLC34A2 are a cause of pulmonary alveolar microlithiasis (PALM) [MIM:265100]. Pulmonary alveolar microlithiasis is a rare disease characterized by the deposition of calcium phosphate microliths throughout the lungs. Most patients are asymptomatic for several years or even for decades and generally, the diagnosis is incidental to clinical investigations unrelated to the disease. Cases with early onset or rapid progression are rare. A 'sandstorm-appearing' chest roentgenogram is a typical diagnostic finding. The onset of this potentially lethal disease varies from the neonatal period to old age and the disease follows a long-term, progressive course, resulting in a slow deterioration of lung functions. Pulmonary alveolar microlithiasis is a recessive monogenic disease with full penetrance.
  • 配列類似性Belongs to the SLC34A transporter family.
  • 細胞内局在Membrane.
  • Information by UniProt
  • 参照データベース
  • 別名
    • Na(+)-dependent phosphate cotransporter 2B antibody
    • Na(+)/Pi cotransporter 2B antibody
    • NaPi-2b antibody
    • NaPi3b antibody
    • NPT2B_HUMAN antibody
    • SLC34A2 antibody
    • Sodium-dependent phosphate transport protein 2B antibody
    • Sodium-phosphate transport protein 2B antibody
    • Sodium/phosphate cotransporter 2B antibody
    • Solute carrier family 34 member 2 antibody
    see all

Anti-SLC34A2 antibody 画像

  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) analysis of human lung tissue labelling SLC34A2 with ab122431. Staining shows strong cytoplasmic positivity in pneumocytes.

Anti-SLC34A2 antibody (ab122431) 使用論文

ab122431 has not yet been referenced specifically in any publications.

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