Anti-SLC31A1 / CTR1 抗体 [EPR7936] (ab129067)
Key features and details
- Produced recombinantly (animal-free) for high batch-to-batch consistency and long term security of supply
- Rabbit monoclonal [EPR7936] to SLC31A1 / CTR1
- Suitable for: WB
- Reacts with: Human
Related conjugates and formulations
製品の概要
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製品名
Anti-SLC31A1 / CTR1 antibody [EPR7936]
SLC31A1 / CTR1 一次抗体 製品一覧 -
製品の詳細
Rabbit monoclonal [EPR7936] to SLC31A1 / CTR1 -
由来種
Rabbit -
アプリケーション
適用あり: WBmore details
適用なし: Flow Cyt,ICC/IF,IHC-P or IP -
種交差性
交差種: Human -
免疫原
Synthetic peptide within Human SLC31A1/ CTR1 aa 1-100 (extracellular). The exact sequence is proprietary.
(Peptide available asab166648) -
ポジティブ・コントロール
- HeLa, Human ovary cancer, Human fetal kidney and Caco 2 lysates.
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特記事項
This product is a recombinant monoclonal antibody, which offers several advantages including:
- - High batch-to-batch consistency and reproducibility
- - Improved sensitivity and specificity
- - Long-term security of supply
- - Animal-free production
Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb® patents.
製品の特性
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製品の状態
Liquid -
保存方法
Shipped at 4°C. Store at -20°C. Stable for 12 months at -20°C. -
解離定数(KD 値)
KD = 1.26 x 10 -10 M Learn more about KD -
バッファー
pH: 7.20
Preservative: 0.01% Sodium azide
Constituents: 9% PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, 50% Tissue culture supernatant -
Concentration information loading...
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精製度
Protein A purified -
ポリ/モノ
モノクローナル -
クローン名
EPR7936 -
アイソタイプ
IgG -
研究分野
関連製品
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Alternative Versions
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Compatible Secondaries
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Isotype control
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Positive Controls
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Recombinant Protein
アプリケーション
The Abpromise guarantee
Abpromise保証は、 次のテスト済みアプリケーションにおけるab129067の使用に適用されます
アプリケーションノートには、推奨の開始希釈率がありますが、適切な希釈率につきましてはご検討ください。
アプリケーション | Abreviews | 特記事項 |
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WB | (2) |
1/1000 - 1/10000. Detects a band of approximately 28,35 kDa (predicted molecular weight: 21 kDa).
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特記事項 |
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WB
1/1000 - 1/10000. Detects a band of approximately 28,35 kDa (predicted molecular weight: 21 kDa). |
ターゲット情報
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機能
High-affinity, saturable copper transporter involved in dietary copper uptake. -
配列類似性
Belongs to the copper transporter (Ctr) (TC 1.A.56) family. SLC31A subfamily. -
翻訳後修飾
O-Glycosylation at Thr-27 protects from proteolytic cleavage in the N-terminal extracellular domain. -
細胞内局在
Cell membrane. Localizes to the apical membrane in intestinal epithelial cells. - Information by UniProt
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参照データベース
- Entrez Gene: 1317 Human
- Omim: 603085 Human
- SwissProt: O15431 Human
- Unigene: 532315 Human
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別名
- Copper transport 1 homolog antibody
- Copper transporter 1 antibody
- COPT1 antibody
see all
画像
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All lanes : Anti-SLC31A1 / CTR1 antibody [EPR7936] (ab129067) at 1/1000 dilution
Lane 1 : HeLa cell lysate
Lane 2 : Human ovary cancer lysate
Lane 3 : Human fetal kidney lysate
Lane 4 : Caco 2 cell lysate
Lysates/proteins at 10 µg per lane.
Secondary
All lanes : Goat anti-rabbit HRP at 1/2000 dilution
Predicted band size: 21 kDa
データシートおよび資料
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SDS download
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Datasheet download
参考文献 (21)
ab129067 は 21 報の論文で使用されています。
- Manyanga J et al. Electronic cigarette aerosols alter the expression of cisplatin transporters and increase drug resistance in oral cancer cells. Sci Rep 11:1821 (2021). PubMed: 33469038
- Wu G et al. ZNF711 down-regulation promotes CISPLATIN resistance in epithelial ovarian cancer via interacting with JHDM2A and suppressing SLC31A1 expression. EBioMedicine 71:103558 (2021). PubMed: 34521054
- Cheng C et al. PTBP1 modulates osteosarcoma chemoresistance to cisplatin by regulating the expression of the copper transporter SLC31A1. J Cell Mol Med 24:5274-5289 (2020). PubMed: 32207235
- Wang Q et al. Preclinical PET imaging study of lung cancer with 64CuCl2. Ann Nucl Med 34:653-662 (2020). PubMed: 32567008
- Curnock R & Cullen PJ Mammalian copper homeostasis requires retromer-dependent recycling of the high-affinity copper transporter 1. J Cell Sci 133:N/A (2020). PubMed: 32843536