The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
追加情報IHC-P: Use at a concentration of 1 - 2 µg/ml.
WB: Use at a concentration of 1 - 5 µg/ml.
Not yet tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.
This antibody has only been tested in WB against the recombinant fragment used as immunogen. We have no data on the detection of endogenous protein.
機能Chloride/bicarbonate exchanger. Involved in absorbtion of in the colon. Helps mediate electrolyte and fluid absorption.
関連疾患Defects in SLC26A3 are the cause of diarrhea type 1 (DIAR1) [MIM:214700]; also known as congenital chloride diarrhea (CLD). DIAR1 is a disease characterized by voluminous watery stools containing an excess of chloride. The children with this disease are often premature.
配列類似性Belongs to the SLC26A/SulP transporter (TC 2.A.53) family. Contains 1 STAS domain.
発生段階Expression is significantly decreased in adenomas (polyps) and adenocarcinomas of the colon.
翻訳後修飾Phosphorylated upon DNA damage, probably by ATM or ATR.