製品の概要

  • 製品名Anti-SLC25A13 antibody
    SLC25A13 一次抗体 製品一覧
  • 製品の詳細
    Rabbit polyclonal to SLC25A13
  • アプリケーション適用あり: WBmore details
  • 種交差性
    交差種: Human
    交差が予測される動物種: Mouse, Cow, Zebrafish
  • 免疫原

    Recombinant fragment, corresponding to a sequence within amino acids 248-505 of Human SLC25A13.

  • ポジティブ・コントロール
    • 293T, A431, H1299, HeLa, HepG2, Molt4 or Raji whole cell lysate.

法規制情報

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab96303 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB 1/500 - 1/3000. Predicted molecular weight: 74 kDa.

ターゲット情報

  • 機能Catalyzes the calcium-dependent exchange of cytoplasmic glutamate with mitochondrial aspartate across the mitochondrial inner membrane. May have a function in the urea cycle.
  • 組織特異性High levels in liver and low levels in kidney, pancreas, placenta, heart and brain.
  • 関連疾患Defects in SLC25A13 are the cause of citrullinemia type 2 (CTLN2) [MIM:603471]. Citrullinemia belongs to the urea cycle disorders. It is an autosomal recessive disease characterized primarily by elevated serum and urine citrulline levels. Ammonia intoxication is another manifestation. CTLN2 is characterized by neuropsychiatric symptoms including abnormal behaviors, loss of memory, seizures and coma. Death can result from brain edema. Onset is sudden and usually between the ages of 20 and 50 years.
    Defects in SLC25A13 are the cause of neonatal intrahepatic cholestasis due to citrin deficiency (NICCD) [MIM:605814]. NICCD is a form of citrullinemia type 2 with neonatal onset. NICCD is characterized by suppression of the bile flow, hepatic fibrosis, low birth weight, growth retardation, hypoproteinemia, variable liver dysfunction. NICCD is generally not severe and symptoms disappear by one year of age with an appropriate diet. Years or even decades later, however, some individuals develop the characteristic features of citrullinemia type 2 with neuropsychiatric symptoms.
  • 配列類似性Belongs to the mitochondrial carrier family.
    Contains 4 EF-hand domains.
    Contains 3 Solcar repeats.
  • 細胞内局在Mitochondrion inner membrane.
  • Information by UniProt
  • 参照データベース
  • 別名
    • AI785475 antibody
    • ARALAR2 antibody
    • Calcium binding mitochondrial carrier protein Aralar2 antibody
    • Calcium-binding mitochondrial carrier protein Aralar2 antibody
    • Citrin antibody
    • CMC2_HUMAN antibody
    • CTLN2 antibody
    • Ctrn antibody
    • Mitochondrial aspartate glutamate carrier 2 antibody
    • RGD1565889 antibody
    • Slc25a13 antibody
    • Solute carrier family 25 (citrin) member 13 antibody
    • Solute carrier family 25 member 13 (citrin) antibody
    • Solute carrier family 25 member 13 antibody
    see all

Anti-SLC25A13 antibody 画像

  • Anti-SLC25A13 antibody (ab96303) at 1/1000 dilution + 293T whole cell lysate at 30 µg

    Predicted band size : 74 kDa

Anti-SLC25A13 antibody (ab96303) 使用論文

ab96303 has not yet been referenced specifically in any publications.

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