製品の概要

  • 製品名Anti-SLC22A4 antibody
    SLC22A4 一次抗体 製品一覧
  • 製品の詳細
    Rabbit polyclonal to SLC22A4
  • アプリケーション適用あり: WBmore details
  • 種交差性
    交差種: Human
  • 免疫原

    Synthetic peptide conjugated to KLH, corresponding to a region within C terminal amino acids 521-550 of Human SLC22A4 (NP_003050.2).

  • ポジティブ・コントロール
    • HeLa cell line lysates.

製品の特性

関連製品

アプリケーション

Our Abpromise guarantee covers the use of ab107727 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB 1/100 - 1/500. Predicted molecular weight: 62 kDa.

ターゲット情報

  • 機能Sodium-ion dependent, low affinity carnitine transporter. Probably transports one sodium ion with one molecule of carnitine. Also transports organic cations such as tetraethylammonium (TEA) without the involvement of sodium. Relative uptake activity ratio of carnitine to TEA is 1.78. A key substrate of this transporter seems to be ergothioneine (ET).
  • 組織特異性Widely expressed. Highly expressed in whole blood, bone marrow, trachea and fetal liver. Weakly expressed in kidney, skeletal muscle, prostate, lung, pancreas, placenta, heart, uterus, spleen and spinal cord. Highly expressed in intestinal cell types affected by Crohn disease, including epithelial cells. Expressed in CD68 macrophage and CD43 T-cells but not in CD20 B-cells. Predominantly expressed in CD14 cells in peripheral blood mononuclear cells.
  • 関連疾患Genetic variations in SLC22A4 are a cause of susceptibility to rheumatoid arthritis (RA) [MIM:180300]. It is a systemic inflammatory disease with autoimmune features and a complex genetic component. It primarily affects the joints and is characterized by inflammatory changes in the synovial membranes and articular structures, widespread fibrinoid degeneration of the collagen fibers in mesenchymal tissues, and by atrophy and rarefaction of bony structures.
  • 配列類似性Belongs to the major facilitator superfamily. Organic cation transporter family.
  • 細胞内局在Membrane.
  • Information by UniProt
  • 参照データベース
  • 別名
    • Ergothioneine transporter antibody
    • ET transporter antibody
    • integral membrane transport protein antibody
    • LSTP Like 2 antibody
    • MGC34546 antibody
    • MGC40524 antibody
    • Octn1 antibody
    • Organic cation transporter 1 antibody
    • Organic cation/carnitine transporter 1 antibody
    • RP23-354D12.1 antibody
    • S22A4_HUMAN antibody
    • Slc22a4 antibody
    • Solute carrier family (organic cation transporter), member 4 antibody
    • solute carrier family 22 (organic cation/zwitterion transporter), member 4 antibody
    • Solute carrier family 22 member 4 antibody
    see all

Anti-SLC22A4 antibody 画像

  • Anti-SLC22A4 antibody (ab107727) at 1/100 dilution + HeLa cell line lysates at 35 µg

    Predicted band size : 62 kDa

Anti-SLC22A4 antibody (ab107727) 使用論文

This product has been referenced in:
  • Li RW  et al. Uptake and protective effects of ergothioneine in human endothelial cells. J Pharmacol Exp Ther 350:691-700 (2014). Human . Read more (PubMed: 25022513) »

See 1 Publication for this product

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