製品の概要

  • 製品名Anti-SLC22A1 antibody
    SLC22A1 一次抗体 製品一覧
  • 製品の詳細
    Rabbit polyclonal to SLC22A1
  • アプリケーション適用あり: WBmore details
  • 種交差性
    交差種: Human
  • 免疫原

    Synthetic peptide conjugated to KLH, corresponding to a region within C terminal amino acids 510-539 of Human SLC22A1 (O15245, NP_003048.1, NP_694857.1).

  • ポジティブ・コントロール
    • HepG2 cell line lysates.

製品の特性

  • 製品の状態Liquid
  • 保存方法Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term.
  • バッファーPreservative: 0.09% Sodium azide
    Constituent: 99% PBS
  • Concentration information loading...
  • 精製度Immunogen affinity purified
  • 特記事項(精製)ab123128 is purified through a protein A column, followed by peptide affinity purification.
  • ポリ/モノポリクローナル
  • アイソタイプIgG
  • 研究分野

アプリケーション

Our Abpromise guarantee covers the use of ab123128 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB 1/100 - 1/500. Predicted molecular weight: 61 kDa.

ターゲット情報

  • 機能Translocates a broad array of organic cations with various structures and molecular weights including the model compounds 1-methyl-4-phenylpyridinium (MPP), tetraethylammonium (TEA), N-1-methylnicotinamide (NMN), 4-(4-(dimethylamino)styryl)-N-methylpyridinium (ASP), the endogenous compounds choline, guanidine, histamine, epinephrine, adrenaline, noradrenaline and dopamine, and the drugs quinine, and metformin. The transport of organic cations is inhibited by a broad array of compounds like tetramethylammonium (TMA), cocaine, lidocaine, NMDA receptor antagonists, atropine, prazosin, cimetidine, TEA and NMN, guanidine, cimetidine, choline, procainamide, quinine, tetrabutylammonium, and tetrapentylammonium. Translocates organic cations in an electrogenic and pH-independent manner. Translocates organic cations across the plasma membrane in both directions. Transports the polyamines spermine and spermidine. Transports pramipexole across the basolateral membrane of the proximal tubular epithelial cells. The choline transport is activated by MMTS. Regulated by various intracellular signaling pathways including inhibition by protein kinase A activation, and endogenously activation by the calmodulin complex, the calmodulin-dependent kinase II and LCK tyrosine kinase.
  • 組織特異性Widely expressed with high level in liver. Isoform 1 and isoform 2 are expressed in liver. Isoform 1, isoform 2, isoform 3 and isoform 4 are expressed in glial cell lines.
  • 配列類似性Belongs to the major facilitator superfamily. Organic cation transporter family.
  • 翻訳後修飾Phosphorylated.
  • 細胞内局在Basolateral cell membrane.
  • Information by UniProt
  • 参照データベース
  • 別名
    • hOCT1 antibody
    • OCT1 antibody
    • oct1_cds antibody
    • Organic cation transporter 1 antibody
    • S22A1_HUMAN antibody
    • Slc22a1 antibody
    • solute carrier family 22 (organic cation transporter), member 1 antibody
    • Solute carrier family 22 member 1 antibody
    see all

Anti-SLC22A1 antibody 画像

  • Anti-SLC22A1 antibody (ab123128) at 1/100 dilution + HepG2 cell line lysates at 35 µg

    Predicted band size : 61 kDa

Anti-SLC22A1 antibody (ab123128) 使用論文

This product has been referenced in:
  • Hubeny A  et al. Expression of Organic Anion Transporting Polypeptide 1A2 in Red Blood Cells and Its Potential Impact on Antimalarial Therapy. Drug Metab Dispos 44:1562-8 (2016). Read more (PubMed: 27504015) »

See 1 Publication for this product

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"