Anti-SLC16A3/MCT 4 抗体 (ab74109)
Key features and details
- Rabbit polyclonal to SLC16A3/MCT 4
- Suitable for: WB
- Reacts with: Human
- Isotype: IgG
製品の概要
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製品名
Anti-SLC16A3/MCT 4 antibody
SLC16A3/MCT 4 一次抗体 製品一覧 -
製品の詳細
Rabbit polyclonal to SLC16A3/MCT 4 -
由来種
Rabbit -
アプリケーション
適用あり: WBmore details -
種交差性
交差種: Human
交差が予測される動物種: Mouse, Rat -
免疫原
Synthetic peptide. This information is proprietary to Abcam and/or its suppliers.
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ポジティブ・コントロール
- Extracts from LOVO cells
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特記事項
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
製品の特性
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製品の状態
Liquid -
保存方法
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles. -
バッファー
pH: 7.40
Preservative: 0.02% Sodium azide
Constituents: 50% Glycerol, 0.87% Sodium chloride, PBS -
Concentration information loading...
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精製度
Immunogen affinity purified -
特記事項(精製)
The antibody was affinity purified from rabbit antiserum by affinity chromatography using epitope specific immunogen. -
ポリ/モノ
ポリクローナル -
アイソタイプ
IgG -
研究分野
関連製品
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Compatible Secondaries
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Isotype control
アプリケーション
The Abpromise guarantee
Abpromise保証は、 次のテスト済みアプリケーションにおけるab74109の使用に適用されます
アプリケーションノートには、推奨の開始希釈率がありますが、適切な希釈率につきましてはご検討ください。
アプリケーション | Abreviews | 特記事項 |
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WB | (2) |
1/500 - 1/1000. Predicted molecular weight: 49 kDa.
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特記事項 |
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WB
1/500 - 1/1000. Predicted molecular weight: 49 kDa. |
ターゲット情報
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機能
Proton-linked monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and the ketone bodies acetoacetate, beta-hydroxybutyrate and acetate. -
組織特異性
Highly expressed in skeletal muscle. -
配列類似性
Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family. -
細胞内局在
Cell membrane. - Information by UniProt
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参照データベース
- Entrez Gene: 9123 Human
- Entrez Gene: 80879 Mouse
- Entrez Gene: 80878 Rat
- Omim: 603877 Human
- SwissProt: O15427 Human
- SwissProt: P57787 Mouse
- SwissProt: O35910 Rat
- Unigene: 500761 Human
see all -
製品の状態
Lactic acid and pyruvate transport across plasma membranes is catalyzed by members of the proton linked monocarboxylate transporter (MCT) family, which has been designated solute carrier family 16. Each MCT appears to have slightly different substrate and inhibitor specificities and transport kinetics, which are related to the metabolic requirements of the tissues in which it is found. The MCTs, which include MCT1 and MCT2, are characterized by 12 predicted transmembrane domains. -
別名
- MCT 4 antibody
- MCT3 antibody
- MCT4 antibody
see all
画像
データシートおよび資料
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SDS download
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Datasheet download
参考文献 (10)
ab74109 は 10 報の論文で使用されています。
- Kieran NW et al. MicroRNA-210 regulates the metabolic and inflammatory status of primary human astrocytes. J Neuroinflammation 19:10 (2022). PubMed: 34991629
- Cluntun AA et al. The pyruvate-lactate axis modulates cardiac hypertrophy and heart failure. Cell Metab 33:629-648.e10 (2021). PubMed: 33333007
- Yang S et al. LINC00035 Transcriptional Regulation of SLC16A3 via CEBPB Affects Glycolysis and Cell Apoptosis in Ovarian Cancer. Evid Based Complement Alternat Med 2021:5802082 (2021). PubMed: 34671407
- Zhao D et al. Altered expression of lactate dehydrogenase and monocarboxylate transporter involved in lactate metabolism in broiler wooden breast. Poult Sci 99:11-20 (2020). PubMed: 32416791
- Sun K et al. Oxidized ATM-mediated glycolysis enhancement in breast cancer-associated fibroblasts contributes to tumor invasion through lactate as metabolic coupling. EBioMedicine 41:370-383 (2019). PubMed: 30799198
- Brosel S et al. An auditory brainstem nucleus as a model system for neuronal metabolic demands. Eur J Neurosci 47:222-235 (2018). PubMed: 29205598
- Chatel B et al. Moderate and intense muscular exercises induce marked intramyocellular metabolic acidosis in sickle cell disease mice. J Appl Physiol (1985) 122:1362-1369 (2017). PubMed: 28280108
- England EM et al. Chronic activation of AMP-activated protein kinase increases monocarboxylate transporter 2 and 4 expression in skeletal muscle. J Anim Sci 95:3552-3562 (2017). PubMed: 28805903
- Zawislak A et al. Neuron-derived transthyretin modulates astrocytic glycolysis in hormone-independent manner. Oncotarget 8:106625-106638 (2017). PubMed: 29290976
- Ghorbel MT et al. Changes in renal medulla gene expression in a pre-clinical model of post cardiopulmonary bypass acute kidney injury. BMC Genomics 15:916 (2014). PubMed: 25331815