製品の概要

  • 製品名Anti-SLC12A3 antibody
    SLC12A3 一次抗体 製品一覧
  • 製品の詳細
    Rabbit polyclonal to SLC12A3
  • アプリケーション適用あり: WBmore details
  • 種交差性
    交差種: Human
    交差が予測される動物種: Mouse, Rat, Rabbit, Horse, Chicken, Guinea pig, Cow, Cat, Dog, Zebrafish
  • 免疫原

    Synthetic peptide corresponding to a region within internal sequence amino acids 980-1029 (ALIVITLPIG RKGKCPSSLY MAWLETLSQD LRPPVILIRG NQENVLTFYC) of Human SLC12A3 (NP_000330).

  • ポジティブ・コントロール
    • ACHN cell lysate

製品の特性

関連製品

アプリケーション

Our Abpromise guarantee covers the use of ab99097 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 114 kDa.Can be blocked with SLC12A3 peptide (ab203575). Good results were obtained when blocked with 5% non-fat dry milk in 0.05% PBS-T.

ターゲット情報

  • 機能Electrically silent transporter system. Mediates sodium and chloride reabsorption.
  • 組織特異性Predominant in kidney.
  • 関連疾患Defects in SLC12A3 are the cause of Gitelman syndrome (GS) [MIM:263800]. GS is an autosomal recessive disorder characterized by hypokalemic alkalosis in combination with hypomagnesemia, low urinary calcium, and increased renin activity associated with normal blood pressure. Patients are often asymptomatic or present transient periods of muscular weakness and tetany, usually accompanied by abdominal pain, vomiting and fever. The phenotype is highly heterogeneous in terms of age at onset and severity. Cardinal features such as hypocalciuria and hypomagnesemia might also change during the life cycle of a given patient. GS has overlapping features with Bartter syndrome.
  • 配列類似性Belongs to the SLC12A transporter family.
  • 細胞内局在Membrane.
  • Information by UniProt
  • 参照データベース
  • 別名
    • FLJ96318 antibody
    • Na Cl cotransporter antibody
    • Na Cl symporter antibody
    • Na-Cl symporter antibody
    • NaCl electroneutral thiazide sensitive cotransporter antibody
    • NCC antibody
    • NCCT antibody
    • S12A3_HUMAN antibody
    • slc12a3 antibody
    • Solute carrier family 12 (sodium/chloride transporters) member 3 antibody
    • Solute carrier family 12 member 3 antibody
    • Thiazide sensitive Na Cl cotransporter antibody
    • Thiazide sensitive sodium chloride cotransporter antibody
    • Thiazide-sensitive sodium-chloride cotransporter antibody
    • TSC antibody
    see all

Anti-SLC12A3 antibody 画像

  • Anti-SLC12A3 antibody (ab99097) at 1 µg/ml + ACHN cell lsyate at 10 µg

    Predicted band size : 114 kDa

Anti-SLC12A3 antibody (ab99097) 使用論文

ab99097 has not yet been referenced specifically in any publications.

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