Anti-SLC12A3 抗体 (ab95302)
Key features and details
- Rabbit polyclonal to SLC12A3
- Suitable for: ICC/IF, WB
- Reacts with: Mouse, Rat, Human
- Isotype: IgG
製品の概要
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製品名
Anti-SLC12A3 antibody
SLC12A3 一次抗体 製品一覧 -
製品の詳細
Rabbit polyclonal to SLC12A3 -
由来種
Rabbit -
アプリケーション
適用あり: ICC/IF, WBmore details -
種交差性
交差種: Mouse, Rat, Human -
免疫原
Synthetic peptide:
PGEPRKVRPTLADLHSFLKQEG
, corresponding to N terminal amino acids 74-95 of Rat SLC12A3 (NP_062218) -
ポジティブ・コントロール
- Rat kidney tissue lysate.
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特記事項
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
製品の特性
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製品の状態
Liquid -
保存方法
Shipped at 4°C. Store at -20°C. Stable for 12 months at -20°C. -
バッファー
Preservative: 0.007% Sodium azide
Constituents: 0.1% BSA, 50% Glycerol -
Concentration information loading...
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精製度
Immunogen affinity purified -
ポリ/モノ
ポリクローナル -
アイソタイプ
IgG -
研究分野
関連製品
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Compatible Secondaries
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Isotype control
アプリケーション
The Abpromise guarantee
Abpromise保証は、 次のテスト済みアプリケーションにおけるab95302の使用に適用されます
アプリケーションノートには、推奨の開始希釈率がありますが、適切な希釈率につきましてはご検討ください。
アプリケーション | Abreviews | 特記事項 |
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ICC/IF |
1/200.
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WB |
1/1000. Detects a band of approximately 160 kDa (predicted molecular weight: 111 kDa).
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特記事項 |
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ICC/IF
1/200. |
WB
1/1000. Detects a band of approximately 160 kDa (predicted molecular weight: 111 kDa). |
ターゲット情報
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機能
Electrically silent transporter system. Mediates sodium and chloride reabsorption. -
組織特異性
Predominant in kidney. -
関連疾患
Defects in SLC12A3 are the cause of Gitelman syndrome (GS) [MIM:263800]. GS is an autosomal recessive disorder characterized by hypokalemic alkalosis in combination with hypomagnesemia, low urinary calcium, and increased renin activity associated with normal blood pressure. Patients are often asymptomatic or present transient periods of muscular weakness and tetany, usually accompanied by abdominal pain, vomiting and fever. The phenotype is highly heterogeneous in terms of age at onset and severity. Cardinal features such as hypocalciuria and hypomagnesemia might also change during the life cycle of a given patient. GS has overlapping features with Bartter syndrome. -
配列類似性
Belongs to the SLC12A transporter family. -
細胞内局在
Membrane. - Information by UniProt
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参照データベース
- Entrez Gene: 6559 Human
- Entrez Gene: 20497 Mouse
- Entrez Gene: 54300 Rat
- Omim: 600968 Human
- SwissProt: P55017 Human
- SwissProt: P59158 Mouse
- SwissProt: P55018 Rat
- Unigene: 669115 Human
see all -
別名
- FLJ96318 antibody
- Na Cl cotransporter antibody
- Na Cl symporter antibody
see all
画像
データシートおよび資料
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SDS download
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Datasheet download
参考文献 (6)
ab95302 は 6 報の論文で使用されています。
- Hanai S et al. Hypoxia-induced thyroid hormone receptor expression regulates cell-cycle progression in renal tubule epithelial cells. Endocr J 68:1309-1320 (2021). PubMed: 34108302
- Jobbagy S et al. Nrf2 activation protects against lithium-induced nephrogenic diabetes insipidus. JCI Insight 5:N/A (2020). PubMed: 31941842
- Wang LJ et al. PGF2a stimulates the 10-pS Cl- channel and thiazide-sensitive Na+-Cl- cotransporter in the distal convoluted tubule. Am J Physiol Renal Physiol 319:F414-F422 (2020). PubMed: 32715760
- Tang TT et al. Extracellular vesicle-encapsulated IL-10 as novel nanotherapeutics against ischemic AKI. Sci Adv 6:eaaz0748 (2020). PubMed: 32851154
- Zhang J et al. Critical role of the SPAK protein kinase CCT domain in controlling blood pressure. Hum Mol Genet 24:4545-58 (2015). PubMed: 25994507
- Schumacher FR et al. Characterisation of the Cullin-3 mutation that causes a severe form of familial hypertension and hyperkalaemia. EMBO Mol Med 7:1285-306 (2015). PubMed: 26286618