製品の概要

  • 製品名Anti-Slap antibody
    Slap 一次抗体 製品一覧
  • 製品の詳細
    Mouse monoclonal to Slap
  • アプリケーション適用あり: WBmore details
  • 種交差性
    交差種: Human
  • 免疫原

    Recombinant full length protein, corresponding to amino acids 1-277 of Human Slap

製品の特性

  • 製品の状態Liquid
  • 保存方法Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
  • バッファーPreservative: None
    PBS, pH 7.2
  • Concentration information loading...
  • 精製度Protein G purified
  • ポリ/モノモノクローナル
  • アイソタイプIgG2b
  • 軽鎖の種類kappa
  • 研究分野

アプリケーション

Our Abpromise guarantee covers the use of ab58290 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB
  • 追加情報WB: Use at a concentration of 1-5 µg/ml.

    This antibody has only been tested in WB against the recombinant fragment used as immunogen. We have no data on the detection of endogenous protein.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • ターゲット情報

    • 機能Adapter protein, which negatively regulates T-cell receptor (TCR) signaling. Inhibits T-cell antigen-receptor induced activation of nuclear factor of activated T-cells. Involved in the negative regulation of positive selection and mitosis of T-cells. May act by linking signaling proteins such as ZAP70 with CBL, leading to a CBL dependent degradation of signaling proteins.
    • 組織特異性Expressed in lung and fetal brain. Weakly expressed in heart, adult brain, placenta, liver, skeletal muscle, kidney and pancreas.
    • 配列類似性Contains 1 SH2 domain.
      Contains 1 SH3 domain.
    • ドメインThe C-terminal domain is essential for the homodimerization and the interaction with CBL. While the interaction with CBL is apparently mediated via the hydrophobic region of this domain, the highly charged region is apparently required for the homodimerization.
    • 細胞内局在Cytoplasm. Endosome. Colocalizes with endosomes.
    • Information by UniProt
    • 参照データベース
    • 別名
      • hSLAP antibody
      • SLA 1 antibody
      • sla antibody
      • SLA1 antibody
      • SLAP 1 antibody
      • SLAP antibody
      • SLAP-1 antibody
      • SLAP1 antibody
      • SLAP1_HUMAN antibody
      • Src like adapter antibody
      • Src like adapter protein 1 antibody
      • Src like adaptor antibody
      • SRC-like-adapter antibody
      • Src-like-adapter protein 1 antibody
      see all

    Anti-Slap antibody 画像

    • Western blot against tagged recombinant protein immunogen using ab58290 Slap antibody at 1ug/ml. Predicted band size of immunogen is 56 kDa

    Anti-Slap antibody (ab58290) 使用論文

    ab58290 has not yet been referenced specifically in any publications.

    Product Wall

    There are currently no Abreviews or Questions for ab58290.
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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"