Inositol 5-phosphatase which acts on inositol 1,4,5-trisphosphate, inositol 1,3,4,5-tetrakisphosphate, phosphatidylinositol 4,5-bisphosphate and phosphatidylinositol 3,4,5-triphosphate. Has 6-fold higher affinity for phosphatidylinositol 4,5-bisphosphate than for inositol 1,4,5-trisphosphate. May negatively regulate assembly of the actin cytoskeleton.
Ubiquitously expressed with highest levels in skeletal muscle, heart and kidney.
Belongs to the inositol-1,4,5-trisphosphate 5-phosphatase type II family.
Endoplasmic reticulum. Following stimulation with EGF, translocates to membrane ruffles.
Wu MY et al. SNW1 is a critical regulator of spatial BMP activity, neural plate border formation, and neural crest specification in vertebrate embryos. PLoS Biol9:e1000593 (2011).
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