Highly potent GABAB agonist, 10-fold more potent than Baclofen (ab120149). (EC50 values for depression of striatal synaptic potentials are 920 nM and 1.25 μM for SKF97541 and baclofen, respectively).
Also available in simple stock solutions (ab146688) - add 1 ml of water to get an exact, ready-to-use concentration.
Store at Room Temperature. Store under desiccating conditions. The product can be stored for up to 12 months.
Soluble in water to 100 mM
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Bräuner-Osborne H & Krogsgaard-Larsen P Functional pharmacology of cloned heterodimeric GABAB receptors expressed in mammalian cells. Br J Pharmacol128:1370-4 (1999).
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Seabrook GR et al. Electrophysiological characterization of potent agonists and antagonists at pre- and postsynaptic GABAB receptors on neurones in rat brain slices. Br J Pharmacol101:949-57 (1990).
Read more (PubMed: 1964824) »