製品の概要

  • 製品名Anti-SKAP55 antibody
    SKAP55 一次抗体 製品一覧
  • 製品の詳細
    Mouse monoclonal to SKAP55
  • アプリケーション適用あり: WBmore details
  • 種交差性
    交差種: Human
  • 免疫原

    Recombinant fragment: MQAAALPEEI RWLLEDAEEF LAEGLRNENL SAVARDHRDH ILRGFQQIKA RYYWDFQPQG GDIGQDSSDD NHSGTLGLSL TSDAPFLSDY QDEGMEDIVK , corresponding to amino acids 1-101 of Human SKAP55

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab56336 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB
  • 追加情報WB: Use at a concentration of 1-5 µg/ml.


    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • ターゲット情報

    • 機能Positively regulates T-cell receptor signaling by enhancing the MAP kinase pathway. Required for optimal conjugation between T-cells and antigen-presenting cells by promoting the clustering of integrin ITGAL on the surface of T-cells. May be involved in high affinity immunoglobulin epsilon receptor signaling in mast cells.
    • 組織特異性Highly expressed in thymocytes and peripheral blood lymphocytes. Also expressed in spleen cells and testis. Present in T-cells (at protein level).
    • 配列類似性Belongs to the SKAP family.
      Contains 1 PH domain.
      Contains 1 SH3 domain.
    • ドメインThe SH3 domain interacts with FYB.
    • 翻訳後修飾Phosphorylated on tyrosines. Phosphorylation by FYN on Tyr-271 is required for GRB2 interaction. Phosphorylation by FYN on Tyr-295 abolishes interaction with FYB. Tyr-232 is dephosphorylated by PTPRC.
    • 細胞内局在Cytoplasm. Nucleus. Cell membrane. Upon T-cell stimulation, translocates to lipid rafts at the cell membrane.
    • Information by UniProt
    • 参照データベース
    • 別名
      • pp55 antibody
      • SCAP 1 antibody
      • SCAP1 antibody
      • SKAP 1 antibody
      • SKAP 55 antibody
      • SKAP-55 antibody
      • Skap1 antibody
      • SKAP1_HUMAN antibody
      • SKAP55 adaptor protein antibody
      • SRC family associated phosphoprotein 1 antibody
      • Src family-associated phosphoprotein 1 antibody
      • Src kinase associated phosphoprotein 1 antibody
      • SRC kinase associated phosphoprotein 55 kD antibody
      • Src kinase associated phosphoprotein of 55 kDa antibody
      • Src kinase-associated phosphoprotein 1 antibody
      • Src kinase-associated phosphoprotein of 55 kDa antibody
      see all

    Anti-SKAP55 antibody 画像



    • Predicted band size : 41 kDa
      SKAP55 antibody (ab56336) at 1ug/lane + Jurkat cell lysate at 25ug/lane.

    Anti-SKAP55 antibody (ab56336) 使用論文

    ab56336 has not yet been referenced specifically in any publications.

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    There are currently no Abreviews or Questions for ab56336.
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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"