製品の概要

  • 製品名Anti-SKA1 antibody
    SKA1 一次抗体 製品一覧
  • 製品の詳細
    Rabbit polyclonal to SKA1
  • 特異性This antibody is specific for SKA1 and will not crossreact with SKA2 or SKA3.
  • アプリケーション適用あり: WB, ELISAmore details
  • 種交差性
    交差種: Mouse, Rat, Human
  • 免疫原

    A 13 amino acid synthetic peptide from near the C terminus of Human SKA1 (GenBank accession/UniProt ID: Q96BD8).

  • ポジティブ・コントロール
    • A549 cell lysate

製品の特性

  • 製品の状態Liquid
  • 保存方法Shipped at 4°C. Store at +4°C.
  • バッファーPreservative: 0.02% Sodium Azide
    Constituents: PBS
  • Concentration information loading...
  • 精製度Immunogen affinity purified
  • 特記事項(精製)Affinity chromatography purified via peptide column.
  • ポリ/モノポリクローナル
  • アイソタイプIgG
  • 研究分野

アプリケーション

Our Abpromise guarantee covers the use of ab91550 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB Use a concentration of 0.5 - 1 µg/ml. Predicted molecular weight: 29 kDa.
ELISA Use at an assay dependent dilution.

ターゲット情報

  • 機能Component of the SKA1 complex, a microtubule-binding subcomplex of the outer kinetochore that is essential for proper chromosome segregation. Required for timely anaphase onset during mitosis, when chromosomes undergo bipolar attachment on spindle microtubules leading to silencing of the spindle checkpoint. The SKA1 complex is a direct component of the kinetochore-microtubule interface and directly associates with microtubules as oligomeric assemblies. The complex facilitates the processive movement of microspheres along a microtubule in a depolymerization-coupled manner. In the complex, it mediates the interaction with microtubules.
  • 配列類似性Belongs to the SKA1 family.
  • 細胞内局在Cytoplasm > cytoskeleton > spindle. Chromosome > centromere > kinetochore. Localizes to the outer kinetochore and spindle microtubules during mitosis in a NDC80 complex-dependent manner. Localizes to both the mitotic spindle and kinetochore-associated proteins. Associates with kinetochores following microtubule attachment from prometaphase, through mid-anaphase and then vanishes in telophase.
  • Information by UniProt
  • 参照データベース
  • 別名
    • 2810433K01Rik antibody
    • AV117428 antibody
    • C18orf24 antibody
    • MGC10200 antibody
    • Ska1 antibody
    • SKA1_HUMAN antibody
    • Spindle and kinetochore associated complex subunit 1 antibody
    • Spindle and kinetochore associated protein 1 antibody
    • Spindle and kinetochore-associated protein 1 antibody
    • Spindle and KT (kinetochore) associated 1 antibody
    • Spindle and KT associated 1 antibody
    see all

Anti-SKA1 antibody 画像

  • Lane 1 : Anti-SKA1 antibody (ab91550) at 0.5 µg/ml
    Lane 2 : Anti-SKA1 antibody (ab91550) at 1 µg/ml

    Lane 1 : A549 cell lysate
    Lane 2 : A549 cell lysate

    Lysates/proteins at 15 µg per lane.


    Predicted band size : 29 kDa

Anti-SKA1 antibody (ab91550) 使用論文

ab91550 has not yet been referenced specifically in any publications.

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