製品の概要

  • 製品名Anti-SKA1 antibody
    SKA1 一次抗体 製品一覧
  • 製品の詳細
    Rabbit polyclonal to SKA1
  • アプリケーション適用あり: WB, ELISA, IHC-Pmore details
  • 種交差性
    交差種: Human
    交差が予測される動物種: Mouse, Rat
  • 免疫原

    Synthetic peptide conjugated to KLH, derived from the C-terminus of Human SKA1.

  • ポジティブ・コントロール
    • A549 cell lysate; Human Brain, Cerebellum and Cortex tissues

製品の特性

  • 製品の状態Liquid
  • 保存方法Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term.
  • バッファーPreservative: 0.02% Sodium azide
    Constituent: 99% PBS
  • Concentration information loading...
  • 精製度Immunogen affinity purified
  • ポリ/モノポリクローナル
  • アイソタイプIgG
  • 研究分野

アプリケーション

Our Abpromise guarantee covers the use of ab118586 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB Use a concentration of 0.5 - 1 µg/ml. Predicted molecular weight: 29 kDa.
ELISA Use at an assay dependent concentration.
IHC-P Use a concentration of 5 µg/ml.

ターゲット情報

  • 機能Component of the SKA1 complex, a microtubule-binding subcomplex of the outer kinetochore that is essential for proper chromosome segregation. Required for timely anaphase onset during mitosis, when chromosomes undergo bipolar attachment on spindle microtubules leading to silencing of the spindle checkpoint. The SKA1 complex is a direct component of the kinetochore-microtubule interface and directly associates with microtubules as oligomeric assemblies. The complex facilitates the processive movement of microspheres along a microtubule in a depolymerization-coupled manner. In the complex, it mediates the interaction with microtubules.
  • 配列類似性Belongs to the SKA1 family.
  • 細胞内局在Cytoplasm > cytoskeleton > spindle. Chromosome > centromere > kinetochore. Localizes to the outer kinetochore and spindle microtubules during mitosis in a NDC80 complex-dependent manner. Localizes to both the mitotic spindle and kinetochore-associated proteins. Associates with kinetochores following microtubule attachment from prometaphase, through mid-anaphase and then vanishes in telophase.
  • Information by UniProt
  • 参照データベース
  • 別名
    • 2810433K01Rik antibody
    • AV117428 antibody
    • C18orf24 antibody
    • MGC10200 antibody
    • Ska1 antibody
    • SKA1_HUMAN antibody
    • Spindle and kinetochore associated complex subunit 1 antibody
    • Spindle and kinetochore associated protein 1 antibody
    • Spindle and kinetochore-associated protein 1 antibody
    • Spindle and KT (kinetochore) associated 1 antibody
    • Spindle and KT associated 1 antibody
    see all

Anti-SKA1 antibody 画像

  • Lane 1 : Anti-SKA1 antibody (ab118586) at 0.5 µg/ml
    Lane 2 : Anti-SKA1 antibody (ab118586) at 1 µg/ml

    Lane 1 : A549 cell lysate
    Lane 2 : A549 cell lysate


    Predicted band size : 29 kDa
  • ab118586, at 5 µg/ml, staining SKA1 in formalin-fixed, paraffin-embedded Human Brain, Cerebellum tissue by Immunohistochemistry.
  • ab118586, at 5 µg/ml, staining SKA1 in formalin-fixed, paraffin-embedded Human Brain, Cortex tissue by Immunohistochemistry.

Anti-SKA1 antibody (ab118586) 使用論文

ab118586 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"