製品の概要

  • 製品名Anti-SIX1 antibody
    SIX1 一次抗体 製品一覧
  • 製品の詳細
    Rabbit polyclonal to SIX1
  • アプリケーション適用あり: WBmore details
  • 種交差性
    交差種: Mouse, Human
  • 免疫原

    Three synthetic peptides (human) conjugated to KLH

  • ポジティブ・コントロール
    • An induced culture of E. coli

法規制情報

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab86028 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB
  • 追加情報WB: 1/1000. Detects a band of approximately 46 kDa (predicted molecular weight: 32 kDa). Tag is 14kDa.


    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • ターゲット情報

    • 機能May be involved in limb tendon and ligament development.
    • 組織特異性Specifically expressed in skeletal muscle.
    • 関連疾患Defects in SIX1 are the cause of deafness autosomal dominant type 23 (DFNA23) [MIM:605192]. A form of non-syndromic deafness characterized by prelingual, bilateral, symmetric hearing loss with a conductive component present in some but not all patients.
      Defects in SIX1 are the cause of branchiootic syndrome type 3 (BOS3) [MIM:608389]. BOS3 is a syndrome characterized by usually bilateral branchial cleft fistulas or cysts, sensorineural and/or conductive hearing loss, pre-auricular pits, and structural defects of the outer, middle or inner ear. Otic defects include malformed and hypoplastic pinnae, a narrowed external ear canal, bulbous internal auditory canal, stapes fixation, malformed and hypoplastic cochlea. Branchial and otic anomalies are as those seen in individuals with the branchiootorenal syndrome. However, renal anomalies are absent in branchiootic syndrome patients.
      Note=Defects in SIX1 could be a cause of branchiootorenal syndrome (BOR). BOR is an autosomal dominant disorder manifested by various combinations of preauricular pits, branchial fistulae or cysts, lacrimal duct stenosis, hearing loss, structural defects of the outer, middle, or inner ear, and renal dysplasia. Associated defects include asthenic habitus, long narrow facies, constricted palate, deep overbite, and myopia. Hearing loss may be due to mondini type cochlear defect and stapes fixation. Penetrance of BOR syndrome is high, although expressivity can be extremely variable.
    • 配列類似性Belongs to the SIX/Sine oculis homeobox family.
      Contains 1 homeobox DNA-binding domain.
    • 細胞内局在Nucleus.
    • Information by UniProt
    • 参照データベース
    • 別名
      • BOS3 antibody
      • DFNA23 antibody
      • Homeobox protein SIX1 antibody
      • OTTHUMP00000179042 antibody
      • Sine oculis homeobox homolog 1 antibody
      • SIX homeobox 1 antibody
      • SIX1 antibody
      • SIX1_HUMAN antibody
      • TIP39 antibody
      see all

    Anti-SIX1 antibody 画像

    • All lanes : Anti-SIX1 antibody (ab86028) at 1/1000 dilution

      Lane 1 : An un-induced culture of E. coli
      Lane 2 : An induced culture of E. coli

      Lysates/proteins at 1/5000 dilution per lane.

      Secondary
      Anti-Rabbit IgG HRP at 1/1000 dilution

      Predicted band size : 32 kDa
      Observed band size : 52 kDa (why is the actual band size different from the predicted?)
      Additional bands at : 40 kDa. We are unsure as to the identity of these extra bands.

      Exposure time : 60 minutes

    Anti-SIX1 antibody (ab86028) 使用論文

    ab86028 has not yet been referenced specifically in any publications.

    Product Wall

    There are currently no Abreviews or Questions for ab86028.
    Please use the links above to contact us or submit feedback about this product.

    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"