製品の概要

  • 製品名Anti-SIRT4 antibody
    SIRT4 一次抗体 製品一覧
  • 製品の詳細
    Rabbit polyclonal to SIRT4
  • アプリケーション適用あり: WBmore details
  • 種交差性
    交差種: Mouse, Rat, Human
  • 免疫原

    Synthetic peptide surrounding amino acid 72 of Rat SIRT4.

  • ポジティブ・コントロール
    • Rat kidney tissue lysate
  • 特記事項The antibody solution should be gently mixed before use

法規制情報

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab124521 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB Use a concentration of 1 - 4 µg/ml. Predicted molecular weight: 32 kDa.

ターゲット情報

  • 機能Acts as NAD-dependent protein lipoamidase, ADP-ribosyl transferase and deacetylase. Catalyzes more efficiently removal of lipoyl- and biotinyl- than acetyl-lysine modifications. Inhibits the pyruvate dehydrogenase complex (PDH) activity via the enzymatic hydrolysis of the lipoamide cofactor from the E2 component, DLAT, in a phosphorylation-independent manner (PubMed:25525879). Catalyzes the transfer of ADP-ribosyl groups onto target proteins, including mitochondrial GLUD1, inhibiting GLUD1 enzyme activity. Acts as a negative regulator of mitochondrial glutamine metabolism by mediating mono ADP-ribosylation of GLUD1: expressed in response to DNA damage and negatively regulates anaplerosis by inhibiting GLUD1, leading to block metabolism of glutamine into tricarboxylic acid cycle and promoting cell cycle arrest (PubMed:16959573, PubMed:17715127). In response to mTORC1 signal, SIRT4 expression is repressed, promoting anaplerosis and cell proliferation. Acts as a tumor suppressor (PubMed:23562301, PubMed:23663782). Also acts as a NAD-dependent protein deacetylase: mediates deacetylation of 'Lys-471' of MLYCD, inhibiting its activity, thereby acting as a regulator of lipid homeostasis (By similarity). Controls fatty acid oxidation by inhibiting PPARA transcriptional activation. Impairs SIRT1:PPARA interaction probably through the regulation of NAD(+) levels (PubMed:24043310). Down-regulates insulin secretion.
  • 組織特異性Detected in vascular smooth muscle and striated muscle. Detected in insulin-producing beta-cells in pancreas islets of Langerhans (at protein level). Widely expressed. Weakly expressed in leukocytes and fetal thymus.
  • 配列類似性Belongs to the sirtuin family. Class II subfamily.
    Contains 1 deacetylase sirtuin-type domain.
  • 細胞内局在Mitochondrion matrix.
  • Information by UniProt
  • 参照データベース
  • 別名
    • MGC130046 antibody
    • MGC130047 antibody
    • MGC57437 antibody
    • NAD dependent deacetylase sirtuin 4 antibody
    • NAD dependent protein deacetylase sirtuin 4 antibody
    • NAD-dependent ADP-ribosyltransferase sirtuin-4 antibody
    • NAD-dependent protein deacetylase sirtuin-4 antibody
    • NAD-dependent protein lipoamidase sirtuin-4, mitochondrial antibody
    • Regulatory protein SIR2 homolog 4 antibody
    • Silent mating type information regulation 2 homolog antibody
    • Sir 2 like 4 antibody
    • SIR 2 like protein 4 antibody
    • Sir2 like 4 antibody
    • SIR2 like protein 4 antibody
    • SIR2-like protein 4 antibody
    • SIR2L 4 antibody
    • SIR2L4 antibody
    • SIR4_HUMAN antibody
    • SIRT 4 antibody
    • Sirt4 antibody
    • Sirtuin (silent mating type information regulation 2 homolog) 4 antibody
    • Sirtuin (silent mating type information regulation 2 homolog) 4 (S. cerevisiae) antibody
    • Sirtuin 4 antibody
    • Sirtuin type 4 antibody
    • Sirtuin-4 antibody
    • Sirtuin4 antibody
    see all

Anti-SIRT4 antibody 画像

  • Anti-SIRT4 antibody (ab124521) at 4 µg/ml + Rat kidney tissue lysate

    Predicted band size : 32 kDa

Anti-SIRT4 antibody (ab124521) 使用論文

ab124521 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"