製品の概要

  • 製品名Anti-Silencer of Death Domain antibody
    Silencer of Death Domain 一次抗体 製品一覧
  • 製品の詳細
    Rabbit polyclonal to Silencer of Death Domain
  • 特異性Human, Mouse, Rat.
  • アプリケーション適用あり: ICC/IF, WBmore details
  • 種交差性
    交差種: Mouse, Rat, Human
  • 免疫原

    Synthetic peptide:

    SALRRSGYGPSDGPSC

    , corresponding to amino acids 2-16 of Human SODD.

  • ポジティブ・コントロール
    • HeLa whole cell lysate or THP-1 whole cell lysate.
  • 特記事項Silencer of Death Domains.


    Apoptosis is induced by certain cytokines including TNF and Fas ligand of the TNF family through their death domain containing receptors, TNF-R1 and Fas. Several novel death receptors including DR3, DR4, DR5, and DR6 were recently identified. Cell death signal is transduced by death domain containing adapter molecules through the interaction with death domain of these death receptors. A novel TNF-R1 interacting protein was recently identifiedand designated SODD for silencer of death domains. SODD associates with the death domain of TNF-R1 and prevents constitutive activation of TNF-R1 signaling. TNF treatment releases SODD and permits adapter molecules such as TRADD recruiting to the active TNF-R1 complex, which activates TNF signaling pathways. SODD also interacts with DR3. SODD is ubiquitously expressed in human tissues and cell lines.

製品の特性

  • 製品の状態Liquid
  • 保存方法Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
  • バッファーPBS with 0.02% sodium azide
  • Concentration information loading...
  • 精製度IgG fraction
  • 特記事項(精製)SODD Antibody is Antibody is DEAE purified.
  • 一次抗体 備考Apoptosis is induced by certain cytokines including TNF and Fas ligand of the TNF family through their death domain containing receptors, TNF-R1 and Fas. Several novel death receptors including DR3, DR4, DR5, and DR6 were recently identified. Cell death signal is transduced by death domain containing adapter molecules through the interaction with death domain of these death receptors. A novel TNF-R1 interacting protein was recently identifiedand designated SODD for silencer of death domains. SODD associates with the death domain of TNF-R1 and prevents constitutive activation of TNF-R1 signaling. TNF treatment releases SODD and permits adapter molecules such as TRADD recruiting to the active TNF-R1 complex, which activates TNF signaling pathways. SODD also interacts with DR3. SODD is ubiquitously expressed in human tissues and cell lines.
  • ポリ/モノポリクローナル
  • アイソタイプIgG
  • 研究分野

関連製品

アプリケーション

Our Abpromise guarantee covers the use of ab2048 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
ICC/IF Use a concentration of 5 µg/ml.
WB 1/500 - 1/2000. Detects a band of approximately 60 kDa.Can be blocked with Silencer of Death Domain peptide (ab8382).

ターゲット情報

Anti-Silencer of Death Domain antibody 画像

  • All lanes : Anti-Silencer of Death Domain antibody (ab2048) at 1/500 dilution

    Lane 1 : HeLa whole cell lysate with absence of blocking peptide
    Lane 2 : THP-1 whole cell lysate with absence of blocking peptide
    Lane 3 : HeLa whole cell lysate with Silencer of Death Domain peptide (ab8382)
    Lane 4 : THP-1 whole cell lysate with Silencer of Death Domain peptide (ab8382)


    Observed band size : 60 kDa (why is the actual band size different from the predicted?)
  • ab2048 at 5µg/ml staining Silencer of Death Domain in Hela cells by ICC/IF 

  • Immunofluorescence of SODD in Hela cells using ab2048 at 20 ug/ml.

Anti-Silencer of Death Domain antibody (ab2048) 使用論文

This product has been referenced in:
  • Boiani M  et al. The stress protein BAG3 stabilizes Mcl-1 protein and promotes survival of cancer cells and resistance to antagonist ABT-737. J Biol Chem 288:6980-90 (2013). WB ; Human . Read more (PubMed: 23341456) »

See 1 Publication for this product

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"