製品の概要

  • 製品名Anti-SIL1 antibody
    SIL1 一次抗体 製品一覧
  • 製品の詳細
    Rabbit polyclonal to SIL1
  • アプリケーション適用あり: WB, ELISAmore details
  • 種交差性
    交差種: Human
    交差が予測される動物種: Mouse, Rat, Rabbit, Horse, Chicken, Guinea pig, Cow, Cat, Dog
  • 免疫原

    Synthetic peptide corresponding to a region within the internal sequence amino acids 359-408 (KLQQYRQVHL LPGLWEQGWC EITAHLLALP EHDAREKVLQ TLGVLLTTCR) of Human SIL1 (NP_001032722).

  • ポジティブ・コントロール
    • HeLa cell lysate

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab82644 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB Use a concentration of 1 µg/ml. Detects a band of approximately 45 kDa (predicted molecular weight: 52 kDa). Good results were obtained when blocked with 5% non-fat dry milk in 0.05% PBS-T.
ELISA Use at an assay dependent concentration.

ELISA titre using peptide based assay 1/312500.

ターゲット情報

  • 機能Required for protein translocation and folding in the endoplasmic reticulum (ER). Functions as a nucleotide exchange factor for the ER lumenal chaperone HSPA5.
  • 組織特異性Highly expressed in tissues which produce large amounts of secreted proteins such as kidney, liver and placenta. Also expressed in colon, heart, lung, ovary, pancreas, peripheral leukocyte, prostate, spleen and thymus. Expressed at low levels throughout the brain.
  • 関連疾患Defects in SIL1 are a cause of Marinesco-Sjoegren syndrome (MSS) [MIM:248800]. MSS is an autosomal recessive multisystem disorder which is characterized by cerebellar ataxia due to cerebellar atrophy, with Purkinje and granule cell loss and myopathy featuring marked muscle replacement with fat and connective tissue. Other cardinal features include bilateral cataracts, hypergonadotrophic hypogonadism and mild to severe mental retardation. Skeletal abnormalities, short stature, dysarthria, strabismus and nystagmus are also frequent findings. Mutational inactivation of this protein may result in ER stress-induced cell death signaling or malfunctioning chaperone machineries that mishandle client proteins which are critical for the organs targeted in MSS.
  • 配列類似性Belongs to the SIL1 family.
  • 発生段階Expressed in fetal kidney, fetal lung, fetal liver and at low levels in fetal brain.
  • 翻訳後修飾N-glycosylated.
  • 細胞内局在Endoplasmic reticulum lumen.
  • Information by UniProt
  • 参照データベース
  • 別名
    • BAP antibody
    • BiP associated protein antibody
    • BiP-associated protein antibody
    • Endoplasmic reticulum chaperone SIL 1 antibody
    • Endoplasmic reticulum chaperone SIL1 antibody
    • MSS antibody
    • Nucleotide exchange factor SIL 1 antibody
    • Nucleotide exchange factor SIL1 antibody
    • SIL 1 antibody
    • sil1 antibody
    • SIL1 homolog antibody
    • SIL1 homolog endoplasmic reticulum chaperone (S. cerevisiae) antibody
    • SIL1 homolog endoplasmic reticulum chaperone antibody
    • SIL1_HUMAN antibody
    • UGL 5 antibody
    • ULG5 antibody
    see all

Anti-SIL1 antibody 画像

Anti-SIL1 antibody (ab82644) 使用論文

ab82644 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"