製品の概要

  • 製品名
    Anti-SIGLEC9 antibody [MM0552-6K12]
    SIGLEC9 一次抗体 製品一覧
  • 製品の詳細
    Mouse monoclonal [MM0552-6K12] to SIGLEC9
  • アプリケーション
    適用あり: ICC/IF, WB, Neutralisingmore details
  • 種交差性
    交差種: Rat, Human
  • 免疫原

    Recombinant fragment of Human SIGLEC9 extracellular domain.

製品の特性

  • 製品の状態
    Liquid
  • 保存方法
    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
  • バッファー
    Preservative: None
    Constituents: PBS
  • Concentration information loading...
  • 精製度
    Protein G purified
  • 特記事項(精製)
    The IgG fraction of culture supernatant was purified by Protein G affinity chromatography and 0.2 µm filtered.
  • ポリ/モノ
    モノクローナル
  • クローン名
    MM0552-6K12
  • アイソタイプ
    IgG2
  • 研究分野

アプリケーション

Our Abpromise guarantee covers the use of ab89484 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
ICC/IF Use at an assay dependent concentration. PubMed: 25673840
WB 1/500 - 1/1000. Predicted molecular weight: 50 kDa.
Neutralising Use at an assay dependent concentration.

ターゲット情報

  • 機能
    Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Preferentially binds to alpha-2,3- or alpha-2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface.
  • 組織特異性
    Expressed by peripheral blood leukocytes (neutrophils and monocytes but not eosinophils). Found in liver, fetal liver, bone marrow, placenta, spleen and in lower levels in skeletal muscle, fetal brain, stomach, lung, thymus, prostate, brain, mammary, adrenal gland, colon, trachea, cerebellum, testis, small intestine and spinal cordon.
  • 配列類似性
    Belongs to the immunoglobulin superfamily. SIGLEC (sialic acid binding Ig-like lectin) family.
    Contains 2 Ig-like C2-type (immunoglobulin-like) domains.
    Contains 1 Ig-like V-type (immunoglobulin-like) domain.
  • ドメイン
    Contains 1 copy of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). This motif is involved in modulation of cellular responses. The phosphorylated ITIM motif can bind the SH2 domain of several SH2-containing phosphatases.
  • 細胞内局在
    Membrane.
  • Information by UniProt
  • 参照データベース
  • 別名
    • CD329 antibody
    • CDw329 antibody
    • FOAP 9 antibody
    • OB binding protein like antibody
    • OBBP LIKE antibody
    • Protein FOAP 9 antibody
    • Protein FOAP-9 antibody
    • sialic acid binding Ig like lectin 9 antibody
    • Sialic acid-binding Ig-like lectin 9 antibody
    • Sialic acid-binding immunoglobulin like lectin 9 antibody
    • SIGL9_HUMAN antibody
    • Siglec 9 antibody
    • Siglec-9 antibody
    • SIGLEC9 antibody
    see all

Anti-SIGLEC9 antibody [MM0552-6K12] (ab89484) 使用論文

This product has been referenced in:
  • Matsubara K  et al. Secreted ectodomain of sialic acid-binding Ig-like lectin-9 and monocyte chemoattractant protein-1 promote recovery after rat spinal cord injury by altering macrophage polarity. J Neurosci 35:2452-64 (2015). ICC/IF ; Rat . Read more (PubMed: 25673840) »
  • Brazil JC  et al. a3/4 Fucosyltransferase 3-dependent synthesis of Sialyl Lewis A on CD44 variant containing exon 6 mediates polymorphonuclear leukocyte detachment from intestinal epithelium during transepithelial migration. J Immunol 191:4804-17 (2013). Read more (PubMed: 24068663) »

See all 2 Publications for this product

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There are currently no Abreviews or Questions for ab89484.
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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