製品の概要

  • 製品名
  • 製品の詳細
    Rabbit polyclonal to SIGLEC6
  • アプリケーション
    適用あり: ELISA, WB, IHC-Pmore details
  • 種交差性
    交差種: Mouse, Human
  • 免疫原

    Synthetic peptide (10-30 aa in length) at the C-term of last 100 aa of human SIGLEC6, conjugated to KLH.

  • ポジティブ・コントロール
    • mouse spleen tissue lysate, human breast carcinoma

製品の特性

  • 製品の状態
    Liquid
  • 保存方法
    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.
  • バッファー
    Preservative: 0.09% Sodium Azide
    Constituents: PBS
  • Concentration information loading...
  • 精製度
    Protein G purified
  • ポリ/モノ
    ポリクローナル
  • アイソタイプ
    IgG
  • 研究分野

アプリケーション

Our Abpromise guarantee covers the use of ab38581 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
ELISA
WB
IHC-P
  • 追加情報
    ELISA: 1/1000.
    IHC-P: Use at an assay dependent dilution (PMID 18974375).
    WB: 1/100 - 1/500. Detects a band of approximately 58 kDa (predicted molecular weight: 49 kDa).


    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • ターゲット情報

    • 機能
      Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Binds to alpha-2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface.
    • 組織特異性
      Expressed at high levels in placenta (cyto- and syncytiotrophoblastic cells) and at lower levels in spleen, peripheral blood leukocytes (predominantly B-cells) and small intestine.
    • 配列類似性
      Belongs to the immunoglobulin superfamily. SIGLEC (sialic acid binding Ig-like lectin) family.
      Contains 2 Ig-like C2-type (immunoglobulin-like) domains.
      Contains 1 Ig-like V-type (immunoglobulin-like) domain.
    • ドメイン
      Contains 1 copy of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). This motif is involved in modulation of cellular responses. The phosphorylated ITIM motif can bind the SH2 domain of several SH2-containing phosphatases.
    • 細胞内局在
      Secreted and Cell membrane.
    • Information by UniProt
    • 参照データベース
    • 別名
      • CD327 antibody
      • CD33 antigen-like 1 antibody
      • CD33L antibody
      • CD33L1 antibody
      • CD33L2 antibody
      • CDw327 antibody
      • OB-BP1 antibody
      • OBBP1 antibody
      • Obesity-binding protein 1 antibody
      • Sialic acid-binding Ig-like lectin 6 antibody
      • SIGL6_HUMAN antibody
      • Siglec-6 antibody
      • SIGLEC6 antibody
      see all

    画像

    • Immunohistochemical analysis of SIGLEC6 expression in formalin-fixed and paraffin-embedded human breast carcinoma tissue using 1/50 ab38581.
    • Anti-SIGLEC6 antibody (ab38581) at 1/100 dilution + Mouse spleen tissue lysate

      Predicted band size : 49 kDa
      Observed band size : 56 kDa (why is the actual band size different from the predicted?)

    参考文献

    This product has been referenced in:
    • Chng WJ  et al. Gene expression profiling of pulmonary mucosa-associated lymphoid tissue (MALT) lymphoma identifies new biological insights with potential diagnostic and therapeutic applications. Blood : (2008). IHC-P ; Human . Read more (PubMed: 18974375) »

    See 1 Publication for this product

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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