製品の概要

  • 製品名Anti-SIGLEC11 antibody
    SIGLEC11 一次抗体 製品一覧
  • 製品の詳細
    Rabbit polyclonal to SIGLEC11
  • 特異性Specific to Human SIGLEC11, does not cross react with SIGLEC10.
  • アプリケーション適用あり: ICC/IF, WB, IHC-Pmore details
  • 種交差性
    交差種: Human
  • 免疫原

    18 amino acid peptide from near the carboxy terminus of Human SIGLEC11 (NP_443116).

  • ポジティブ・コントロール
    • HepG2 cell lysate Human liver tissue

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab106390 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
ICC/IF Use a concentration of 20 µg/ml.
WB Use a concentration of 0.5 - 1 µg/ml. Predicted molecular weight: 76 kDa.
IHC-P Use a concentration of 5 µg/ml.

ターゲット情報

  • 機能Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Preferentially binds to alpha-2,8-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. In the immune response, may act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block signal transduction through dephosphorylation of signaling molecules.
  • 組織特異性Expressed by macrophages in various tissues including Kupffer cells. Also found in brain microglia.
  • 配列類似性Belongs to the immunoglobulin superfamily. SIGLEC (sialic acid binding Ig-like lectin) family.
    Contains 3 Ig-like C2-type (immunoglobulin-like) domains.
    Contains 1 Ig-like V-type (immunoglobulin-like) domain.
  • ドメインContains 1 copy of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). This motif is involved in modulation of cellular responses. The phosphorylated ITIM motif can bind the SH2 domain of several SH2-containing phosphatases.
  • 翻訳後修飾Phosphorylated on tyrosine residues.
  • 細胞内局在Membrane.
  • Information by UniProt
  • 参照データベース
  • 別名
    • sialic acid binding Ig like lectin 11 antibody
    • sialic acid binding lectin 11 antibody
    • Sialic acid-binding Ig-like lectin 11 antibody
    • Sialic acid-binding lectin 11 antibody
    • SIG11_HUMAN antibody
    • Siglec 11 antibody
    • Siglec-11 antibody
    • SIGLEC11 antibody
    see all

Anti-SIGLEC11 antibody 画像

  • Immunofluorescence of SIGLEC11 in Human liver tissue with ab106390 at 20 ug/mL.

  • Anti-SIGLEC11 antibody (ab106390) at 1 µg/ml + HepG2 cell lysate at 15 µg

    Predicted band size : 76 kDa
  • ab106390 at 5µg/ml, staining SIGLEC11 in Human liver, using Immunohistochemistry, Formalin/PFA-fixed paraffin-embedded tissue.

Anti-SIGLEC11 antibody (ab106390) 使用論文

ab106390 has not yet been referenced specifically in any publications.

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