製品の概要

  • 製品名Anti-SIGLEC10 antibody
    SIGLEC10 一次抗体 製品一覧
  • 製品の詳細
    Rabbit polyclonal to SIGLEC10
  • アプリケーション適用あり: WBmore details
  • 種交差性
    交差種: Human
  • 免疫原

    A KLH conjugated synthetic peptide selected from the C-terminal region of Human SIGLEC10.

  • ポジティブ・コントロール
    • HeLa Cell Lysate

製品の特性

  • 製品の状態Liquid
  • 保存方法Shipped at 4°C. Store at 4°C (up to 6 months). Store at -20°C long term.
  • バッファーPreservative: 0.09% Sodium azide
    Constituent: 99% PBS
  • Concentration information loading...
  • 精製度Immunogen affinity purified
  • 特記事項(精製)This antibody is purified through a protein A column, followed by peptide affinity purification.
  • ポリ/モノポリクローナル
  • アイソタイプIgG
  • 研究分野

アプリケーション

Our Abpromise guarantee covers the use of ab112564 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB 1/100 - 1/500. Predicted molecular weight: 77 kDa.

ターゲット情報

  • 機能Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Preferentially binds to alpha-2,3- or alpha-2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. In the immune response, may act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block signal transduction through dephosphorylation of signaling molecules.
  • 組織特異性Expressed by peripheral blood leukocytes (eosinophils, monocytes and a natural killer cell subpopulation). Isoform 5 is found to be the most abundant isoform. Found in lymph node, lung, ovary and appendix. Isoform 1 is found at high levels and isoform 2 at lower levels in bone marrow, spleen and spinal chord. Isoform 2 is also found in brain. Isoform 4 is specifically found in natural killer cells.
  • 配列類似性Belongs to the immunoglobulin superfamily. SIGLEC (sialic acid binding Ig-like lectin) family.
    Contains 3 Ig-like C2-type (immunoglobulin-like) domains.
    Contains 1 Ig-like V-type (immunoglobulin-like) domain.
  • ドメインContains 1 copy of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). This motif is involved in modulation of cellular responses. The phosphorylated ITIM motif can bind the SH2 domain of several SH2-containing phosphatases.
  • 翻訳後修飾Phosphorylation of Tyr-667 is involved in binding to PTPN6.
  • 細胞内局在Secreted and Cell membrane.
  • Information by UniProt
  • 参照データベース
  • 別名
    • mSiglec G antibody
    • PRO940 antibody
    • Sialic acid binding Ig like lectin 10 antibody
    • Sialic acid binding Ig like lectin 10 antibody
    • sialic acid binding Ig like lectin 10 Ig like lectin 7 antibody
    • sialic acid binding Ig like lectin G antibody
    • Sialic acid binding Immunoglobulin like lectin 10 antibody
    • Sialic acid-binding Ig-like lectin 10 antibody
    • SIG10_HUMAN antibody
    • SIGLEC 10 antibody
    • Siglec G antibody
    • siglec like gene 2 antibody
    • Siglec like protein 2 antibody
    • Siglec like protein 2 antibody
    • Siglec-10 antibody
    • Siglec-like protein 2 antibody
    • SIGLEC10 antibody
    • Siglecg antibody
    • SLG2 antibody
    see all

Anti-SIGLEC10 antibody 画像

  • Anti-SIGLEC10 antibody (ab112564) at 1/100 dilution + HeLa Cell Lysate at 35 µg

    Predicted band size : 77 kDa

Anti-SIGLEC10 antibody (ab112564) 使用論文

ab112564 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"