Anti-Siglec 7 抗体 [MM0551-8D8] (ab89483)


  • 製品名Anti-Siglec 7 antibody [MM0551-8D8]
    Siglec 7 一次抗体 製品一覧
  • 製品の詳細
    Mouse monoclonal [MM0551-8D8] to Siglec 7
  • 特異性ab89483 cross reacts with Siglec 14.
  • アプリケーション適用あり: WB, IHC-Pmore details
  • 種交差性
    交差種: Human
  • 免疫原

    Recombinant fragment of Human Siglec 7 extracellular domain.



Our Abpromise guarantee covers the use of ab89483 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
  • 追加情報IHC-P: 1/20 - 1/200.
    WB: 1/500 - 1/1000. Predicted molecular weight: 51 kDa.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • ターゲット情報

    • 機能Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Preferentially binds to alpha-2,3- and alpha-2,6-linked sialic acid. Also binds disialogangliosides (disialogalactosyl globoside, disialyl lactotetraosylceramide and disialyl GalNAc lactotetraoslylceramide). The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. In the immune response, may act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block signal transduction through dephosphorylation of signaling molecules. Mediates inhibition of natural killer cells cytotoxicity. May play a role in hemopoiesis. Inhibits differentiation of CD34+ cell precursors towards myelomonocytic cell lineage and proliferation of leukemic myeloid cells (in vitro).
    • 組織特異性Predominantly expressed by resting and activated natural killer cells and at lower levels by granulocytes and monocytes. High expression found in placenta, liver, lung, spleen, and peripheral blood leukocytes.
    • 配列類似性Belongs to the immunoglobulin superfamily. SIGLEC (sialic acid binding Ig-like lectin) family.
      Contains 2 Ig-like C2-type (immunoglobulin-like) domains.
      Contains 1 Ig-like V-type (immunoglobulin-like) domain.
    • ドメインContains 1 copy of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). This motif is involved in modulation of cellular responses. The phosphorylated ITIM motif can bind the SH2 domain of several SH2-containing phosphatases.
    • 翻訳後修飾Tyrosine phosphorylated.
    • 細胞内局在Membrane.
    • Information by UniProt
    • 参照データベース
    • 別名
      • Adhesion inhibitory receptor molecule 1 antibody
      • Adhesion inhibitory receptor molecule 1, siglec 7 antibody
      • AIRM 1 antibody
      • AIRM-1 antibody
      • AIRM1 antibody
      • CD328 antibody
      • CD328 antigen antibody
      • CDw328 antibody
      • D siglec antibody
      • D-siglec antibody
      • HLDA 8 antibody
      • p75 antibody
      • p75/AIRM1 antibody
      • QA79 antibody
      • QA79 membrane protein antibody
      • Sialic acid binding Ig like lectin 7 antibody
      • Sialic acid binding immunoglobulin like lectin 7 antibody
      • Sialic acid-binding Ig-like lectin 7 antibody
      • SIGL7_HUMAN antibody
      • Siglec-7 antibody
      • SIGLEC19P antibody
      • SIGLEC7 antibody
      • SIGLECP2 antibody
      see all

    Anti-Siglec 7 antibody [MM0551-8D8] (ab89483) 使用論文

    ab89483 has not yet been referenced specifically in any publications.

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