製品の概要

  • 製品名Anti-Siglec 7 antibody
    Siglec 7 一次抗体 製品一覧
  • 製品の詳細
    Rabbit polyclonal to Siglec 7
  • アプリケーション適用あり: ELISA, WB, IHC-Pmore details
  • 種交差性
    交差種: Human
  • 免疫原

    Synthetic peptide conjugated to KLH (10-30 aa in length) at the C terminus of last 100 aa of human Siglec 7.

  • ポジティブ・コントロール
    • Jurkat cell lysate. Human hepatocarcinoma tissue.

製品の特性

関連製品

アプリケーション

Our Abpromise guarantee covers the use of ab38573 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
ELISA 1/1000.
WB 1/100 - 1/500. Detects a band of approximately 51 kDa (predicted molecular weight: 51 kDa).
IHC-P Use at an assay dependent concentration.

ターゲット情報

  • 機能Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Preferentially binds to alpha-2,3- and alpha-2,6-linked sialic acid. Also binds disialogangliosides (disialogalactosyl globoside, disialyl lactotetraosylceramide and disialyl GalNAc lactotetraoslylceramide). The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. In the immune response, may act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block signal transduction through dephosphorylation of signaling molecules. Mediates inhibition of natural killer cells cytotoxicity. May play a role in hemopoiesis. Inhibits differentiation of CD34+ cell precursors towards myelomonocytic cell lineage and proliferation of leukemic myeloid cells (in vitro).
  • 組織特異性Predominantly expressed by resting and activated natural killer cells and at lower levels by granulocytes and monocytes. High expression found in placenta, liver, lung, spleen, and peripheral blood leukocytes.
  • 配列類似性Belongs to the immunoglobulin superfamily. SIGLEC (sialic acid binding Ig-like lectin) family.
    Contains 2 Ig-like C2-type (immunoglobulin-like) domains.
    Contains 1 Ig-like V-type (immunoglobulin-like) domain.
  • ドメインContains 1 copy of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). This motif is involved in modulation of cellular responses. The phosphorylated ITIM motif can bind the SH2 domain of several SH2-containing phosphatases.
  • 翻訳後修飾Tyrosine phosphorylated.
  • 細胞内局在Membrane.
  • Information by UniProt
  • 参照データベース
  • 別名
    • Adhesion inhibitory receptor molecule 1 antibody
    • Adhesion inhibitory receptor molecule 1, siglec 7 antibody
    • AIRM 1 antibody
    • AIRM-1 antibody
    • AIRM1 antibody
    • CD328 antibody
    • CD328 antigen antibody
    • CDw328 antibody
    • D siglec antibody
    • D-siglec antibody
    • HLDA 8 antibody
    • p75 antibody
    • p75/AIRM1 antibody
    • QA79 antibody
    • QA79 membrane protein antibody
    • Sialic acid binding Ig like lectin 7 antibody
    • Sialic acid binding immunoglobulin like lectin 7 antibody
    • Sialic acid-binding Ig-like lectin 7 antibody
    • SIGL7_HUMAN antibody
    • Siglec-7 antibody
    • SIGLEC19P antibody
    • SIGLEC7 antibody
    • SIGLECP2 antibody
    see all

Anti-Siglec 7 antibody 画像

  • Anti-Siglec 7 antibody (ab38573) at 1/100 dilution + Jurkat cell lysate

    Predicted band size : 51 kDa
    Observed band size : 51 kDa
    Additional bands at : 49 kDa. We are unsure as to the identity of these extra bands.
  • Formalin-fixed and paraffin-embedded human hepatocarcinoma tissue reacted with ab38573, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining.

Anti-Siglec 7 antibody (ab38573) 使用論文

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