機能Acts as a negative regulator of the Toll-like and IL-1R receptor signaling pathways. Attenuates the recruitment of receptor-proximal signaling components to the TLR4 receptor, probably through an TIR-TIR domain interaction with TLR4. Through its extracellular domain interferes with the heterodimerization of Il1R1 and IL1RAP.
組織特異性Mainly expressed in epithelial tissues such as kidney, lung and gut.
配列類似性Belongs to the interleukin-1 receptor family. Contains 1 Ig-like C2-type (immunoglobulin-like) domain. Contains 1 TIR domain.