製品の概要

  • 製品名
  • 製品の詳細
    Rabbit polyclonal to SIGIRR
  • アプリケーション
    適用あり: WB, ELISA, IHC-Pmore details
  • 種交差性
    交差種: Human
    交差が予測される動物種: Mouse, Rat, Horse, Chicken, Guinea pig, Cow, Cat, Dog, Pig, Zebrafish
  • 免疫原

    Synthetic peptide corresponding to a region of human SIGIRR (XP_001129013)

  • ポジティブ・コントロール
    • Jurkat cell lysate

製品の特性

  • 製品の状態
    Liquid
  • 保存方法
    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
  • バッファー
    Preservative: None
    Constituents: 2% Sucrose, PBS
  • Concentration information loading...
  • 精製度
    Immunogen affinity purified
  • ポリ/モノ
    ポリクローナル
  • アイソタイプ
    IgG
  • 研究分野

アプリケーション

Our Abpromise guarantee covers the use of ab76401 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 25 kDa. Good results were obtained when blocked with 5% non-fat dry milk in 0.05% PBS-T.
ELISA Use at an assay dependent concentration.

Titre using peptide based assay, 1:62500.

IHC-P Use a concentration of 5 µg/ml.

ターゲット情報

  • 機能
    Acts as a negative regulator of the Toll-like and IL-1R receptor signaling pathways. Attenuates the recruitment of receptor-proximal signaling components to the TLR4 receptor, probably through an TIR-TIR domain interaction with TLR4. Through its extracellular domain interferes with the heterodimerization of Il1R1 and IL1RAP.
  • 組織特異性
    Mainly expressed in epithelial tissues such as kidney, lung and gut.
  • 配列類似性
    Belongs to the interleukin-1 receptor family.
    Contains 1 Ig-like C2-type (immunoglobulin-like) domain.
    Contains 1 TIR domain.
  • 細胞内局在
    Membrane.
  • Information by UniProt
  • 参照データベース
  • 別名
    • Ig IL1 related receptor antibody
    • MGC110992 antibody
    • SIGIR_HUMAN antibody
    • SIGIRR antibody
    • Single Ig IL 1 related receptor antibody
    • Single Ig IL-1-related receptor antibody
    • Single Ig IL-1R-related molecule antibody
    • Single Ig IL1R Related Molecule antibody
    • Single immunoglobulin and toll interleukin 1 receptor (TIR) domain antibody
    • Single immunoglobulin and toll interleukin 1 receptor domain antibody
    • Single immunoglobulin domain containing IL1R related protein antibody
    • Single immunoglobulin domain IL1R1 related antibody
    • Single immunoglobulin domain-containing IL1R-related protein antibody
    • TIR 8 antibody
    • TIR8 antibody
    • Toll/interleukin 1 receptor 8 antibody
    • Toll/interleukin-1 receptor 8 antibody
    see all

画像

  • Immunohistochemistry of Liver tissue at an antibody concentration of 5 µg/ml using anti-SIGIRR antibody (ab76401)

参考文献

ab76401 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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