Anti-Shwachman Bodian-Diamond syndrome 抗体 (ab59642)


  • 製品名
    Anti-Shwachman Bodian-Diamond syndrome antibody
    Shwachman Bodian-Diamond syndrome 一次抗体 製品一覧
  • 製品の詳細
    Rabbit polyclonal to Shwachman Bodian-Diamond syndrome
  • アプリケーション
    適用あり: WB, IHC-Pmore details
  • 種交差性
    交差種: Human
    交差が予測される動物種: Mouse, Rat, Rabbit, Horse, Chicken, Guinea pig, Cow, Cat, Dog, Pig, Zebrafish
  • 免疫原

    Synthetic peptide: YGQQLEIVCL IDPGCFREID ELIKKETKGK GSLEVLNLKD VEEGDEKFE, corresponding to amino acids 202-250 of Human Shwachman Bodian-Diamond syndrome

  • ポジティブ・コントロール
    • Jurkat cell lysate and Human kidney tissue.


  • 製品の状態
  • 保存方法
    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
  • バッファー
    Preservative: None
    Constituents: 2% Sucrose, PBS
  • Concentration information loading...
  • 精製度
    Protein A purified
  • ポリ/モノ
  • アイソタイプ
  • 研究分野


Our Abpromise guarantee covers the use of ab59642 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB Use a concentration of 1.25 µg/ml. Predicted molecular weight: 29 kDa. Good results were obtained when blocked with 5% non-fat dry milk in 0.05% PBS-T.
IHC-P Use a concentration of 4 - 8 µg/ml.


  • 機能
    Required for the assembly of mature ribosomes and ribosome biogenesis. Together with EFTUD1, triggers the GTP-dependent release of EIF6 from 60S pre-ribosomes in the cytoplasm, thereby activating ribosomes for translation competence by allowing 80S ribosome assembly and facilitating EIF6 recycling to the nucleus, where it is required for 60S rRNA processing and nuclear export. Required for normal levels of protein synthesis. May play a role in cellular stress resistance. May play a role in cellular response to DNA damage. May play a role in cell proliferation.
  • 組織特異性
    Widely expressed.
  • 関連疾患
    Defects in SBDS are the cause of Shwachman-Diamond syndrome (SDS) [MIM:260400]. SDS is an autosomal recessive disorder characterized by pancreatic exocrine insufficiency, hematologic dysfunction, and skeletal abnormalities.
  • 配列類似性
    Belongs to the SDO1/SBDS family.
  • 細胞内局在
    Cytoplasm. Nucleus > nucleolus. Nucleus > nucleoplasm. Cytoplasm > cytoskeleton > spindle. Primarily detected in the cytoplasm, and at low levels in nucleus and nucleolus (PubMed:19602484 and PubMed:17475909). Detected in the nucleolus during G1 and G2 phase of the cell cycle, and diffusely distributed in the nucleus during S phase. Detected at the mitotic spindle. Colocalizes with the microtubule organizing center during interphase.
  • Information by UniProt
  • 参照データベース
  • 別名
    • 4733401P19Rik antibody
    • AI836084 antibody
    • CGI 97 antibody
    • CGI-97 antibody
    • FLJ10917 antibody
    • MGC105922 antibody
    • Protein 22A3 antibody
    • Ribosome maturation protein SBDS antibody
    • sbds antibody
    • SBDS_HUMAN antibody
    • SDS antibody
    • Shwachman Bodian Diamond syndrome protein antibody
    • Shwachman Bodian Diamond syndrome protein homolog antibody
    • Shwachman-Bodian-Diamond syndrome protein antibody
    • SWDS antibody
    see all

Anti-Shwachman Bodian-Diamond syndrome antibody 画像

  • Anti-Shwachman Bodian-Diamond syndrome antibody (ab59642) at 1.25 µg/ml + Jurkat cell lysate at 10 µg

    HRP conjugated anti-Rabbit IgG at 1/50000 dilution

    Predicted band size : 29 kDa
    Observed band size : 29 kDa
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) analysis of human kidney tissue labelling Shwachman Bodian-Diamond syndrome with ab59642 at 4-8µg/ml. Arrows indicate positively labelled epithelial cells of the renal tubule. Magnification: 400X.

Anti-Shwachman Bodian-Diamond syndrome antibody (ab59642) 使用論文

ab59642 has not yet been referenced specifically in any publications.

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