Anti-SHPRH 抗体 [2994C1a] (ab84856)

製品の概要

• 製品名
  Anti-SHPRH antibody [2994C1a]
  SHPRH 一次抗体 製品一覧
• 製品の詳細
  Mouse monoclonal [2994C1a] to SHPRH
• アプリケーション
  適用あり: WB, Dot blotmore details
• 種交差性
  交差種: Recombinant fragment
  交差が予測される動物種: Human
• 免疫原

  Recombinant fragment derived from the central region of Human SHPRH

製品の特性

• 製品の状態
  Liquid
• 保存方法
  Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
• バッファー
  Preservative: 0.05% Sodium Azide
  Constituents: 1% BSA, PBS, pH 7.4
• Concentration information loading...
• 精製度
  Protein G purified
• ポリ/モノ
  モノクローナル
• クローン名
  2994C1a
• アイソタイプ
  IgG1
• 研究分野
  • Cell Biology
  • Proteolysis / Ubiquitin
  • Proteasome / Ubiquitin
  • Ubiquitin E3 Enzymes
  • RING Finger E3 Ligase

  • Epigenetics and Nuclear Signaling
  • Cell cycle
  • Ubiquitin ligases

  • Cancer
  • Oncoproteins/suppressors
  • Tumor suppressors
  • Other

関連製品

• Compatible Secondaries
  • Goat Anti-Mouse IgG H&L (Alexa Fluor® 488) (ab150113)
  • Goat Anti-Mouse IgG H&L (HRP) (ab205719)

アプリケーション

ターゲット情報

• 機能
  E3 ubiquitin-protein ligase involved in DNA repair. Upon genotoxic stress, accepts ubiquitin from the UBE2N-UBE2V2 E2 complex and transfers it to 'Lys-164' of PCNA which had been monoubiquitinated by UBE2A/B-RAD18, promoting the formation of non-canonical poly-ubiquitin chains linked through 'Lys-63'.
• 組織特異性
  Broadly expressed.
• パスウェイ
  Protein modification; protein ubiquitination.
• 配列類似性
  Belongs to the SNF2/RAD54 helicase family.
  Contains 1 H15 (linker histone H1/H5 globular) domain.
  Contains 1 helicase ATP-binding domain.
  Contains 1 helicase C-terminal domain.
  Contains 1 PHD-type zinc finger.
  Contains 1 RING-type zinc finger.
• ドメイン
  The RING finger mediates E3 ubiquitin ligase activity.

• Target information above from: UniProt accession Q149N8 The UniProt Consortium
  The Universal Protein Resource (UniProt) in 2010
  Nucleic Acids Res. 38:D142-D148 (2010) .

  Information by UniProt
• 参照データベース
  • Entrez Gene: 257218 Human
  • Omim: 608048 Human
  • SwissProt: Q149N8 Human
  • Unigene: 723297 Human
• 別名
  • bA545I5.2 antibody
  • E3 ubiquitin-protein ligase SHPRH antibody
  • FLJ27258 antibody

  • FLJ37625 antibody
  • FLJ45012 antibody
  • FLJ90837 antibody
  • histone-linker antibody
  • KIAA2023 antibody
  • MGC134886 antibody
  • PHD and RING finger domain-containing helicase antibody
  • Shprh antibody
  • SHPRH_HUMAN antibody
  • SNF2 antibody
  • SNF2 histone linker PHD RING helicase antibody

  see all

プロトコール

• Western blot protocols