製品の概要

  • 製品名Anti-SHP1 antibody
    SHP1 一次抗体 製品一覧
  • 製品の詳細
    Rabbit polyclonal to SHP1
  • 特異性This antibody detects endogenous levels of total SHP1 protein.
  • アプリケーション適用あり: IHC-P, WB, ELISAmore details
  • 種交差性
    交差種: Mouse, Human
  • 免疫原

    Synthetic non-phosphopeptide derived from human SHP1 around the phosphorylation site of Tyrosine 536 (SEYGN)

  • ポジティブ・コントロール
    • Extracts from NIH/3T3 cells; human breast carcinoma tissue

製品の特性

関連製品

アプリケーション

Our Abpromise guarantee covers the use of ab55356 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
IHC-P Use at an assay dependent concentration.
WB 1/500 - 1/1000. Predicted molecular weight: 68 kDa.
ELISA 1/20000.

ターゲット情報

  • 機能Plays a key role in hematopoiesis. This PTPase activity may directly link growth factor receptors and other signaling proteins through protein-tyrosine phosphorylation. The SH2 regions may interact with other cellular components to modulate its own phosphatase activity against interacting substrates. Together with MTUS1, induces UBE2V2 expression upon angiotensin II stimulation.
  • 組織特異性Isoform 1 is expressed in hematopoietic cells. Isoform 2 is expressed in non-hematopoietic cells.
  • 配列類似性Belongs to the protein-tyrosine phosphatase family. Non-receptor class 2 subfamily.
    Contains 2 SH2 domains.
    Contains 1 tyrosine-protein phosphatase domain.
  • 翻訳後修飾Phosphorylated on serine and tyrosine residues.
  • 細胞内局在Cytoplasm. Nucleus. In neurons, translocates into the nucleus after treatment with angiotensin II.
  • Information by UniProt
  • 参照データベース
  • 別名
    • 70Z-SHP antibody
    • EC 3.1.3.48 antibody
    • HCP antibody
    • HCPH antibody
    • Hematopoietic cell phosphatase antibody
    • Hematopoietic cell protein tyrosine phosphatase antibody
    • Hematopoietic cell protein-tyrosine phosphatase antibody
    • HPTP1C antibody
    • Protein tyrosine phosphatase 1C antibody
    • Protein tyrosine phosphatase non receptor type 6 antibody
    • Protein tyrosine phosphatase SHP1 antibody
    • Protein-tyrosine phosphatase 1C antibody
    • protein-tyrosine phosphatase SHP 1 antibody
    • Protein-tyrosine phosphatase SHP-1 antibody
    • PTN6_HUMAN antibody
    • PTP 1C antibody
    • PTP-1C antibody
    • PTP1C antibody
    • Ptpn6 antibody
    • SH PTP 1 antibody
    • SH PTP1 antibody
    • SH-PTP1 antibody
    • SHP 1 antibody
    • SHP 1L antibody
    • SHP1 antibody
    • SHP1L antibody
    • tyrosine protein phosphatase non receptor type 6 antibody
    • Tyrosine-protein phosphatase non-receptor type 6 antibody
    see all

Anti-SHP1 antibody 画像

  • All lanes : Anti-SHP1 antibody (ab55356) at 1/500 dilution

    Lane 1 : extracts from NIH/3T3 cells with no immunizing peptide
    Lane 2 : extracts from NIH/3T3 cells with immunizing peptide


    Predicted band size : 68 kDa
    Observed band size : 68 kDa
  • Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using ab55356 at 1/50 dilution. Left: without immunizing peptide; Right: with immunizing peptide

Anti-SHP1 antibody (ab55356) 使用論文

This product has been referenced in:
  • Yan D  et al. Inhibition of TLR signaling by a bacterial protein containing immunoreceptor tyrosine-based inhibitory motifs. Nat Immunol 13:1063-71 (2012). Read more (PubMed: 23001144) »

See 1 Publication for this product

Product Wall

There are currently no Abreviews or Questions for ab55356.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"