製品の概要

  • 製品名Anti-SHOX antibody
    SHOX 一次抗体 製品一覧
  • 製品の詳細
    Rabbit polyclonal to SHOX
  • アプリケーション適用あり: WBmore details
  • 種交差性
    交差種: Human
    交差が予測される動物種: Horse, Cow, Cat, Dog, Pig, Zebrafish
  • 免疫原

    Synthetic peptide corresponding to a region within N terminal amino acids 2-51 (EELTAFVSKS FDQKSKDGNG GGGGGGGKKD SITYREVLES GLARSRELGT) of human SHOX (NP_000442).

  • ポジティブ・コントロール
    • Human fetal brain lysate.

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab84804 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 32 kDa. Good results were obtained when blocked with 5% non-fat dry milk in 0.05% PBS-T.

ターゲット情報

  • 機能Controls fundamental aspects of growth and development.
  • 組織特異性SHOXA is expressed in skeletal muscle, placenta, pancreas, heart and bone marrow fibroblast and SHOXB is highly expressed in bone marrow fibroblast followed by kidney and skeletal muscle. SHOXB is not expressed in brain, kidney, liver and lung. Highly expressed in osteogenic cells.
  • 関連疾患Defects in SHOX are the cause of Leri-Weill dyschondrosteosis (LWD) [MIM:127300]. LWD is a dominantly inherited skeletal dysplasia characterized by moderate short stature predominantly because of short mesomelic limb segments. It is often associated with the Madelung deformity of the wrist, comprising bowing of the radius and dorsal dislocation of the distal ulna.
    Defects in SHOX are a cause of Langer mesomelic dysplasia (LMD) [MIM:249700]. LMD is an autosomal recessive rare skeletal dysplasia characterized by severe short stature owing to shortening and maldevelopment of the mesomelic and rhizomelic segments of the limbs. Associated malformations are rarely reported and intellect is normal in all affected subjects reported to date.
    Defects in SHOX are a cause of idiopathic short stature (ISS) [MIM:300582]. Idiopathic short stature is usually defined as a height below the third percentile for chronological age or minus 2 standard deviations of national height standards in the absence of specific causative disorders.
  • 配列類似性Belongs to the paired homeobox family. Bicoid subfamily.
    Contains 1 homeobox DNA-binding domain.
  • 細胞内局在Nucleus.
  • Information by UniProt
  • 参照データベース
  • 別名
    • GCFX antibody
    • Growth control factor, X linked antibody
    • Homo sapiens shox gene, alternatively spliced products, complete cds antibody
    • PHOG antibody
    • Pseudoautosomal homeobox containing osteogenic antibody
    • Pseudoautosomal homeobox containing osteogenic protein antibody
    • Pseudoautosomal homeobox-containing osteogenic protein antibody
    • Short stature homeobox antibody
    • Short stature homeobox containing protein antibody
    • Short stature homeobox protein antibody
    • Short stature homeobox-containing protein antibody
    • SHOX antibody
    • SHOX_HUMAN antibody
    • SHOXY antibody
    • SS antibody
    • Turner syndrome antibody
    see all

Anti-SHOX antibody 画像

  • Anti-SHOX antibody (ab84804) at 1 µg/ml (in 5% skim milk / PBS buffer) + human fetal brain lysate at 10 µg

    Secondary
    HRP conjugated anti-Rabbit IgG at 1/50000 dilution

    Predicted band size : 32 kDa
    Observed band size : 29 kDa (why is the actual band size different from the predicted?)
    Additional bands at : 38 kDa. We are unsure as to the identity of these extra bands.

Anti-SHOX antibody (ab84804) 使用論文

ab84804 has not yet been referenced specifically in any publications.

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