製品の概要

  • 製品名Anti-SHOX antibody
    SHOX 一次抗体 製品一覧
  • 製品の詳細
    Mouse polyclonal to SHOX
  • 特異性This antibody is reactive against mammalian transfected lysate.
  • アプリケーション適用あり: WBmore details
  • 種交差性
    交差種: Human
  • 免疫原

    SHOX (NP_006874.1, 1 a.a. ~ 225 a.a) full-length human protein.

  • ポジティブ・コントロール
    • SHOX transfected 293T cell lysate and human liver tissue lysate

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab67927 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB
  • 追加情報WB: 1/500 - 1/1000. Detects bands of approximately 30 and 36 kDa (predicted molecular weight: 32 kDa).

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • ターゲット情報

    • 機能Controls fundamental aspects of growth and development.
    • 組織特異性SHOXA is expressed in skeletal muscle, placenta, pancreas, heart and bone marrow fibroblast and SHOXB is highly expressed in bone marrow fibroblast followed by kidney and skeletal muscle. SHOXB is not expressed in brain, kidney, liver and lung. Highly expressed in osteogenic cells.
    • 関連疾患Defects in SHOX are the cause of Leri-Weill dyschondrosteosis (LWD) [MIM:127300]. LWD is a dominantly inherited skeletal dysplasia characterized by moderate short stature predominantly because of short mesomelic limb segments. It is often associated with the Madelung deformity of the wrist, comprising bowing of the radius and dorsal dislocation of the distal ulna.
      Defects in SHOX are a cause of Langer mesomelic dysplasia (LMD) [MIM:249700]. LMD is an autosomal recessive rare skeletal dysplasia characterized by severe short stature owing to shortening and maldevelopment of the mesomelic and rhizomelic segments of the limbs. Associated malformations are rarely reported and intellect is normal in all affected subjects reported to date.
      Defects in SHOX are a cause of idiopathic short stature (ISS) [MIM:300582]. Idiopathic short stature is usually defined as a height below the third percentile for chronological age or minus 2 standard deviations of national height standards in the absence of specific causative disorders.
    • 配列類似性Belongs to the paired homeobox family. Bicoid subfamily.
      Contains 1 homeobox DNA-binding domain.
    • 細胞内局在Nucleus.
    • Information by UniProt
    • 参照データベース
    • 別名
      • GCFX antibody
      • Growth control factor, X linked antibody
      • Homo sapiens shox gene, alternatively spliced products, complete cds antibody
      • PHOG antibody
      • Pseudoautosomal homeobox containing osteogenic antibody
      • Pseudoautosomal homeobox containing osteogenic protein antibody
      • Pseudoautosomal homeobox-containing osteogenic protein antibody
      • Short stature homeobox antibody
      • Short stature homeobox containing protein antibody
      • Short stature homeobox protein antibody
      • Short stature homeobox-containing protein antibody
      • SHOX antibody
      • SHOX_HUMAN antibody
      • SHOXY antibody
      • SS antibody
      • Turner syndrome antibody
      see all

    Anti-SHOX antibody 画像

    • Anti-SHOX antibody (ab67927) at 1/500 dilution + human liver tissue lysate at 25 µg

      Secondary
      Goat Anti-Mouse IgG (H&L)-HRP Conjugate at 1/2500 dilution

      Predicted band size : 32 kDa
      Observed band size : 36 kDa (why is the actual band size different from the predicted?)
    • All lanes : Anti-SHOX antibody (ab67927) at 1/500 dilution

      Lane 1 : SHOX transfected 293T cell lysate
      Lane 2 : Non-transfected 293T cell lysate

      Lysates/proteins at 25 µg per lane.

      Secondary
      Goat Anti-Mouse IgG (H&L)-HRP Conjugate at 1/2500 dilution

      Predicted band size : 32 kDa
      Observed band size : 30 kDa (why is the actual band size different from the predicted?)

    Anti-SHOX antibody (ab67927) 使用論文

    ab67927 has not yet been referenced specifically in any publications.

    Product Wall

    There are currently no Abreviews or Questions for ab67927.
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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"