製品の概要

  • 製品名Anti-SHIP antibody, prediluted
    SHIP 一次抗体 製品一覧
  • 製品の詳細
    Rabbit polyclonal to SHIP, prediluted
  • アプリケーション適用あり: IHC-Pmore details
  • 種交差性
    交差種: Human
    交差が予測される動物種: Mouse, Rat
  • 免疫原

    Synthetic peptide corresponding to C-terminal of human SHIP. The amino acid sequence is not available.

  • ポジティブ・コントロール
    • Human tonsil.

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab41837 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
IHC-P
  • 追加情報IHC-P: Use undiluted - for 30 min at RT. Perform heat mediated antigen retrieval before commencing with IHC staining protocol.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • ターゲット情報

    • 機能Phosphatidylinositol (PtdIns) phosphatase that specifically hydrolyzes the 5-phosphate of phosphatidylinositol-3,4,5-trisphosphate (PtdIns(3,4,5)P3) to produce PtdIns(3,4)P2, thereby negatively regulating the PI3K (phosphoinositide 3-kinase) pathways. Acts as a negative regulator of B-cell antigen receptor signaling. Mediates signaling from the FC-gamma-RIIB receptor (FCGR2B), playing a central role in terminating signal transduction from activating immune/hematopoietic cell receptor systems. Acts as a negative regulator of myeloid cell proliferation/survival and chemotaxis, mast cell degranulation, immune cells homeostasis, integrin alpha-IIb/beta-3 signaling in platelets and JNK signaling in B-cells. Regulates proliferation of osteoclast precursors, macrophage programming, phagocytosis and activation and is required for endotoxin tolerance. Involved in the control of cell-cell junctions, CD32a signaling in neutrophils and modulation of EGF-induced phospholipase C activity. Key regulator of neutrophil migration, by governing the formation of the leading edge and polarization required for chemotaxis. Modulates FCGR3/CD16-mediated cytotoxicity in NK cells. Mediates the activin/TGF-beta-induced apoptosis through its Smad-dependent expression. May also hydrolyze PtdIns(1,3,4,5)P4, and could thus affect the levels of the higher inositol polyphosphates like InsP6.
    • 組織特異性Specifically expressed in immune and hematopoietic cells. Expressed in bone marrow and blood cells. Levels vary considerably within this compartment. Present in at least 74% of immature CD34+ cells, whereas within the more mature population of CD33+ cells, it is present in only 10% of cells. Present in the majority of T-cells, while it is present in a minority of B-cells (at protein level).
    • 配列類似性Belongs to the inositol-1,4,5-trisphosphate 5-phosphatase family.
      Contains 1 SH2 domain.
    • ドメインThe SH2 domain interacts with tyrosine phosphorylated forms of proteins such as SHC1 or PTPN11/SHP-2. It competes with that of GRB2 for binding to phosphorylated SHC1 to inhibit the Ras pathway. It is also required for tyrosine phosphorylation.
      The NPXY sequence motif found in many tyrosine-phosphorylated proteins is required for the specific binding of the PID domain.
    • 翻訳後修飾Tyrosine phosphorylated by the members of the SRC family after exposure to a diverse array of extracellular stimuli such as cytokines, growth factors, antibodies, chemokines, integrin ligands and hypertonic and oxidative stress. Phosphorylated upon IgG receptor FCGR2B-binding.
    • 細胞内局在Cytoplasm. Membrane. Translocates to the plasma membrane when activated, translocation is probably due to different mechanisms depending on the stimulus and cell type. Partly translocated via its SH2 domain which mediates interaction with tyrosine phosphorylated receptors such as the FC-gamma-RIIB receptor (FCGR2B) or CD16/FCGR3. Tyrosine phosphorylation may also participate to membrane localization.
    • Information by UniProt
    • 参照データベース
    • 別名
      • Inositol polyphosphate 5 phosphatase of 145kDa antibody
      • 4 antibody
      • 5-trisphosphate 5-phosphatase 1 antibody
      • hp51CN antibody
      • Inositol polyphosphate 5 phosphatase 145kDa antibody
      • Inositol polyphosphate 5 phosphatase antibody
      • Inositol polyphosphate-5-phosphatase of 145 kDa antibody
      • INPP5D antibody
      • MGC104855 antibody
      • MGC142140 antibody
      • MGC142142 antibody
      • p150Ship antibody
      • Phosphatidylinositol 3,4,5 trisphosphate 5 phosphatase 1 antibody
      • Phosphatidylinositol-3 antibody
      • SH2 containing inositol phosphatase isoform b antibody
      • SH2 domain containing inositol 5' phosphatase 1 antibody
      • SH2 domain containing inositol phosphatase 1 antibody
      • SH2 domain-containing inositol phosphatase 1 antibody
      • SH2 domain-containing inositol-5''-phosphatase 1 antibody
      • SHIP-1 antibody
      • SHIP1 antibody
      • SHIP1_HUMAN antibody
      • Signaling inositol polyphosphate 5 phosphatase SIP 145 antibody
      • SIP-145 antibody
      • SIP145 antibody
      see all

    Anti-SHIP antibody, prediluted 画像

    • Ab41837 staining human SHIP in human tonsil by immunohistochemistry (undiluted) using formalin-fixed paraffin embedded tissue.

    Anti-SHIP antibody, prediluted (ab41837) 使用論文

    ab41837 has not yet been referenced specifically in any publications.

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