製品の概要

  • 製品名Anti-SHB antibody
    SHB 一次抗体 製品一覧
  • 製品の詳細
    Rabbit polyclonal to SHB
  • アプリケーション適用あり: WBmore details
  • 種交差性
    交差種: Human
    交差が予測される動物種: Mouse, Rat, Rabbit, Chicken, Cow, Dog
  • 免疫原

    Synthetic peptide corresponding to a region within the N terminal amino acids 1-50,

    MAKWLNKYFSLGNSKTKSPPQPPRPDYREQRRRGERPSQPPQAVPQASSA

    , of Human SHB (NP_003019)

  • ポジティブ・コントロール
    • HepG2 cell lysate

製品の特性

関連製品

アプリケーション

Our Abpromise guarantee covers the use of ab98007 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 55 kDa. Good results were obtained when blocked with 5% non-fat dry milk in 0.05% PBS-T.

ターゲット情報

  • 機能Adapter protein which regulates several signal transduction cascades by linking activated receptors to downstream signaling components. May play a role in angiogenesis by regulating FGFR1, VEGFR2 and PDGFR signaling. May also play a role in T-cell antigen receptor/TCR signaling, interleukin-2 signaling, apoptosis and neuronal cells differentiation by mediating basic-FGF and NGF-induced signaling cascades. May also regulate IRS1 and IRS2 signaling in insulin-producing cells.
  • 組織特異性Widely expressed.
  • 配列類似性Contains 1 SH2 domain.
  • ドメインThe SH2 domain preferentially binds phosphopeptides with the consensus sequence Y-[TVI]-X-L and mediates interaction with PDGFRA, PDGFRB, FGRFR1, IL2RB, IL2RG, CD3Z and CRK/CrKII.
  • 翻訳後修飾Phosphorylated upon PDGFRA, PDGFRB, TCR, IL2 receptor, FGFR1 or VEGFR2 activation.
  • 細胞内局在Cytoplasm. Cell membrane. Associates with membrane lipid rafts upon TCR stimulation.
  • Information by UniProt
  • 参照データベース
  • 別名
    • bA3J10.2 antibody
    • OTTHUMP00000021397 antibody
    • RP11 3J10.8 antibody
    • RP113J10.8 antibody
    • SH2 domain containing adapter protein B antibody
    • SH2 domain-containing adapter protein B antibody
    • SHB (Src homology 2 domain containing) adaptor protein B antibody
    • SHB adaptor protein (a Src homology 2 protein) antibody
    • SHB adaptor protein antibody
    • Shb antibody
    • SHB_HUMAN antibody
    • Src homology 2 domain containing adaptor protein B antibody
    • Src homology 2 protein antibody
    see all

Anti-SHB antibody 画像

  • Anti-SHB antibody (ab98007) at 1 µg/ml (in 5% skim milk/ PBS buffer) + HepG2 cell lysate at 10 µg

    Secondary
    HRP conjugated anti-Rabbit IgG at 1/50000 dilution

    Predicted band size : 55 kDa

Anti-SHB antibody (ab98007) 使用論文

ab98007 has not yet been referenced specifically in any publications.

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