製品の概要

  • 製品名Anti-SHB antibody
    SHB 一次抗体 製品一覧
  • 製品の詳細
    Rabbit polyclonal to SHB
  • アプリケーション適用あり: ELISA, IHC-Pmore details
  • 種交差性
    交差種: Human
  • 免疫原

    A KLH conjugated synthetic peptide selected from the N terminal region of human SHB

  • ポジティブ・コントロール
    • Human lung carcinoma tissue

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab80239 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
ELISA 1/1000.
IHC-P 1/10 - 1/50.

ターゲット情報

  • 機能Adapter protein which regulates several signal transduction cascades by linking activated receptors to downstream signaling components. May play a role in angiogenesis by regulating FGFR1, VEGFR2 and PDGFR signaling. May also play a role in T-cell antigen receptor/TCR signaling, interleukin-2 signaling, apoptosis and neuronal cells differentiation by mediating basic-FGF and NGF-induced signaling cascades. May also regulate IRS1 and IRS2 signaling in insulin-producing cells.
  • 組織特異性Widely expressed.
  • 配列類似性Contains 1 SH2 domain.
  • ドメインThe SH2 domain preferentially binds phosphopeptides with the consensus sequence Y-[TVI]-X-L and mediates interaction with PDGFRA, PDGFRB, FGRFR1, IL2RB, IL2RG, CD3Z and CRK/CrKII.
  • 翻訳後修飾Phosphorylated upon PDGFRA, PDGFRB, TCR, IL2 receptor, FGFR1 or VEGFR2 activation.
  • 細胞内局在Cytoplasm. Cell membrane. Associates with membrane lipid rafts upon TCR stimulation.
  • Information by UniProt
  • 参照データベース
  • 別名
    • bA3J10.2 antibody
    • OTTHUMP00000021397 antibody
    • RP11 3J10.8 antibody
    • RP113J10.8 antibody
    • SH2 domain containing adapter protein B antibody
    • SH2 domain-containing adapter protein B antibody
    • SHB (Src homology 2 domain containing) adaptor protein B antibody
    • SHB adaptor protein (a Src homology 2 protein) antibody
    • SHB adaptor protein antibody
    • Shb antibody
    • SHB_HUMAN antibody
    • Src homology 2 domain containing adaptor protein B antibody
    • Src homology 2 protein antibody
    see all

Anti-SHB antibody 画像

  • ab80239, at a 1/10 dilution, staining SHB in formalin fixed, paraffin embedded human lung carcinoma tissue by Immunohistochemistry. A peroxidase conjugated secondary antibody was used, followed by DAB staining.

Anti-SHB antibody (ab80239) 使用論文

ab80239 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"