The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
1/10 - 1/50.
機能Adapter protein which regulates several signal transduction cascades by linking activated receptors to downstream signaling components. May play a role in angiogenesis by regulating FGFR1, VEGFR2 and PDGFR signaling. May also play a role in T-cell antigen receptor/TCR signaling, interleukin-2 signaling, apoptosis and neuronal cells differentiation by mediating basic-FGF and NGF-induced signaling cascades. May also regulate IRS1 and IRS2 signaling in insulin-producing cells.
配列類似性Contains 1 SH2 domain.
ドメインThe SH2 domain preferentially binds phosphopeptides with the consensus sequence Y-[TVI]-X-L and mediates interaction with PDGFRA, PDGFRB, FGRFR1, IL2RB, IL2RG, CD3Z and CRK/CrKII.
翻訳後修飾Phosphorylated upon PDGFRA, PDGFRB, TCR, IL2 receptor, FGFR1 or VEGFR2 activation.
細胞内局在Cytoplasm. Cell membrane. Associates with membrane lipid rafts upon TCR stimulation.
ab80239, at a 1/10 dilution, staining SHB in formalin fixed, paraffin embedded human lung carcinoma tissue by Immunohistochemistry. A peroxidase conjugated secondary antibody was used, followed by DAB staining.
Anti-SHB antibody (ab80239) 使用論文
has not yet been referenced specifically in any publications.