製品の概要

  • 製品名Anti-SH3TC2 antibody
    SH3TC2 一次抗体 製品一覧
  • 製品の詳細
    Rabbit polyclonal to SH3TC2
  • 特異性ab111197 detects endogenous levels of total SH3TC2 protein.
  • アプリケーション適用あり: IHC-Pmore details
  • 種交差性
    交差種: Human
  • 免疫原

    Synthetic peptide derived from an internal region of Human SH3TC2.

  • ポジティブ・コントロール
    • Human brain tissue.

製品の特性

  • 製品の状態Liquid
  • 保存方法Shipped at 4°C. Store at -20°C. Stable for 12 months at -20°C.
  • バッファーpH: 7.40
    Preservative: 0.02% Sodium azide
    Constituents: 50% Glycerol, 0.88% Sodium chloride, 49.1% PBS
    Note: PBS (without Mg2+ and Ca2+)
  • Concentration information loading...
  • 精製度Immunogen affinity purified
  • 特記事項(精製)ab111197 was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • ポリ/モノポリクローナル
  • アイソタイプIgG
  • 研究分野

アプリケーション

Our Abpromise guarantee covers the use of ab111197 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
IHC-P 1/50 - 1/100. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.

ターゲット情報

  • 組織特異性Strongly expressed in brain and spinal cord. Expressed at equal level in spinal cord and sciatic nerve. Weakly expressed in striated muscle.
  • 関連疾患Defects in SH3TC2 are the cause of Charcot-Marie-Tooth disease type 4C (CMT4C) [MIM:601596]. CMT4C is a recessive form of Charcot-Marie-Tooth disease, the most common inherited disorder of the peripheral nervous system. Charcot-Marie-Tooth disease is classified in two main groups on the basis of electrophysiologic properties and histopathology: primary peripheral demyelinating neuropathy and primary peripheral axonal neuropathy. Demyelinating CMT neuropathies are characterized by severely reduced nerve conduction velocities (less than 38 m/sec), segmental demyelination and remyelination with onion bulb formations on nerve biopsy, slowly progressive distal muscle atrophy and weakness, absent deep tendon reflexes, and hollow feet. By convention, autosomal recessive forms of demyelinating Charcot-Marie-Tooth disease are designated CMT4. CMT4C is characterized by onset in childhood, early-onset scoliosis and a distinct Schwann cell pathology.
    Defects in SH3TC2 are the cause of mononeuropathy of the median nerve mild (MNMN) [MIM:613353]. A disease characterized by median nerve mononeuropathy at the wrist. The clinical presentation ranges from a mild phenotype, consistent with carpal tunnel syndrome, to a severe median nerve mononeuropathy at the wrist associated with evidence of a more widespread axonal polyneuropathy. The latter phenotype is similar to that of patients with hereditary neuropathy with liability to pressure palsies.
  • 配列類似性Contains 1 SH3 domain.
    Contains 8 TPR repeats.
  • Information by UniProt
  • 参照データベース
  • 別名
    • CMT4C antibody
    • D430044G18Rik antibody
    • FLJ13605 antibody
    • KIAA1985 antibody
    • MNMN antibody
    • PP12494 antibody
    • RGD1309038 antibody
    • S3TC2_HUMAN antibody
    • SH3 domain and tetratricopeptide repeats-containing protein 2 antibody
    • SH3TC2 antibody
    see all

Anti-SH3TC2 antibody 画像

  • ab111197 at 1/50 dilution staining SH3TC2 in paraffin-embedded Human Brain tissue by Immunohistochemistry. The image on the right is treated with the synthesized peptide.

Anti-SH3TC2 antibody (ab111197) 使用論文

ab111197 has not yet been referenced specifically in any publications.

Product Wall

Thank you for contacting us.

The amino acid range for this immunogen is aa#380-430 of human SH3TC2 with acc#Q8TF17 (http://www.uniprot.org/uniprot/Q8TF17). This antibody will bind to isoform 1 based on prediction. It will not bind to isoforms ...

Read More

DISCOUNT CODE: XXXXXX


Expiration date: 15/04/2013

Value: £227.00



I am very pleased to hear you would like to accept our offer and test ab111197 in WB with HeLa cells. This code will give you £22...

Read More

Thank you for your reply.

As long as one of the parameters to be tested (applications or species) is already stated on the datasheet, the Abreview system is elegible.

In this case, if you wish to test the antibody in WB, please make...

Read More

Thank you for contacting us.

According to the expression profile of this protein it shows a moderate pattern in brain tissues:

http://www.proteinatlas.org/ENSG00000169247

The antibody ab111197 detects the endogenous protei...

Read More

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"