製品の概要

  • 製品名
  • 製品の詳細
    Rabbit polyclonal to SH3PXD2B
  • アプリケーション
    適用あり: IHC-P, WBmore details
  • 種交差性
    交差種: Human
  • 免疫原

    antigen sequence, corresponding to amino acids 556-642 (PPGVILPMMP AKHIPPARDS RRPEPKPDKS RLFQLKNDMG LECGHKVLAK EVKKPNLRPI SKSKTDLPEE KPDATPQNPF LKSRPQV) of Human SH3PXD2B

  • ポジティブ・コントロール
    • Human pancreas tissue; Human tonsil, RT-4 and U-251 MG cell lysates.

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab122342 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
IHC-P 1/200 - 1/500. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.
WB 1/250 - 1/500.

ターゲット情報

  • 機能
    Adapter protein involved in invadopodia and podosome formation and extracellular matrix degradation. Binds matrix metalloproteinases (ADAMs), NADPH oxidases (NOXs) and phosphoinositides. Acts as an organizer protein that allows NOX1-or NOX3-dependent reactive oxygen species (ROS) generation and ROS localization. Plays a role in mitotic clonal expansion during the immediate early stage of adipocyte differentiation.
  • 組織特異性
    Expressed in fibroblasts.
  • 関連疾患
    Defects in SH3PXD2B are the cause of Frank-Ter Haar syndrome (FTHS) [MIM:249420]. It is a syndrome characterized by brachycephaly, wide fontanels, prominent forehead, hypertelorism, prominent eyes, macrocornea with or without glaucoma, full cheeks, small chin, bowing of the long bones and flexion deformity of the fingers.
  • 配列類似性
    Belongs to the SH3PXD2 family.
    Contains 1 PX (phox homology) domain.
    Contains 4 SH3 domains.
  • ドメイン
    The PX domain is required for podosome localization because of its ability to bind phosphatidylinositol 3-phosphate (PtdIns(3)P) and phosphatidylinositol 3,4-biphosphate (PtdIns(3,4)P2) and, to a lesser extent, phosphatidylinositol 4-phosphate (PtdIns(4)P), phosphatidylinositol 5-biphosphate (PtdIns(5)P), and phosphatidylinositol 3,5-biphosphate (PtdIns(3,5)P2). Binds to the third intramolecular SH3 domain.
  • 翻訳後修飾
    Phosphorylated in SRC-transformed cells.
  • 細胞内局在
    Cytoplasm. Cell projection > podosome. Cytoplasmic in normal cells and localizes to podosomes in SRC-transformed cells.
  • Information by UniProt
  • 参照データベース
  • 別名
    • Adapter protein HOFI antibody
    • Factor for adipocyte differentiation 49 antibody
    • FAD49 antibody
    • FLJ20831 antibody
    • FTHS antibody
    • KIAA1295 antibody
    • SH3 and PX domain-containing protein 2B antibody
    • SH3PXD2B antibody
    • SPD2B_HUMAN antibody
    • TKS4 antibody
    • Tyrosine kinase substrate with four SH3 domains antibody
    see all

画像

  • ab122342, at a 1/200 dilution, staining SH3PXD2B in paraffin-embedded Human pancreas tissue by immunohistochemistry.
  • All lanes : Anti-SH3PXD2B antibody (ab122342) at 1/250 dilution

    Lane 1 : RT-4 cell lysate
    Lane 2 : U-251 MG cell lysate
    Lane 3 : Human plasma
    Lane 4 : Human liver lysate
    Lane 5 : Human tonsil lysate

    Developed using the ECL technique

参考文献

ab122342 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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